The efficacy of antenatal steroid therapy is dependent on the duration of low-concentration fetal exposure: evidence from a sheep model of pregnancy
Background Antenatal corticosteroids are among the most important and widely used
interventions to improve outcomes for preterm infants. Antenatal corticosteroid dosing …
interventions to improve outcomes for preterm infants. Antenatal corticosteroid dosing …
Variability in the efficacy of a standardized antenatal steroid treatment was independent of maternal or fetal plasma drug levels: evidence from a sheep model of …
Background Administration of antenatal steroids is standard of care for women assessed to
be at imminent risk of preterm delivery. There is a marked variation in antenatal steroid …
be at imminent risk of preterm delivery. There is a marked variation in antenatal steroid …
The duration of fetal antenatal steroid exposure determines the durability of preterm ovine lung maturation
Background Antenatal corticosteroids (ACS) are the standard of care for maturing the fetal
lung and improving outcomes for preterm infants. Antenatal corticosteroid dosing remains …
lung and improving outcomes for preterm infants. Antenatal corticosteroid dosing remains …
[HTML][HTML] Betamethasone phosphate reduces the efficacy of antenatal steroid therapy and is associated with lower birthweights when administered to pregnant sheep …
T Takahashi, EL Fee, Y Takahashi, M Saito… - American journal of …, 2022 - Elsevier
Background Antenatal corticosteroid therapy is a standard of care for women at imminent
risk of preterm labor. However, the optimal (maximum benefit and minimal risk of side …
risk of preterm labor. However, the optimal (maximum benefit and minimal risk of side …
Maternofetal pharmacokinetics and fetal lung responses in chronically catheterized sheep receiving constant, low-dose infusions of betamethasone phosphate
Background Antenatal steroids are standard of care for cases of anticipated preterm labor to
improve neonatal outcomes. However, steroids are potent drugs, and their use in pregnancy …
improve neonatal outcomes. However, steroids are potent drugs, and their use in pregnancy …
[HTML][HTML] Low-dose antenatal betamethasone treatment achieves preterm lung maturation equivalent to that of the World Health Organization dexamethasone regimen …
Background The intramuscular administration of antenatal steroids to women at risk of
preterm delivery achieves high maternal and fetal plasma steroid concentrations, which are …
preterm delivery achieves high maternal and fetal plasma steroid concentrations, which are …
Antenatal corticosteroid therapy: current strategies and identifying mediators and markers for response
N Falah, DM Haas - Seminars in Perinatology, 2014 - Elsevier
Landmark early work has led to the nearly universal use of antenatal corticosteroids to
accelerate fetal lung maturity with pregnancies complicated by impending preterm birth …
accelerate fetal lung maturity with pregnancies complicated by impending preterm birth …
Fetal versus maternal and gestational age effects of repetitive antenatal glucocorticoids
Background. Although single courses of antenatal glucocorticoids decrease respiratory
distress syndrome and mortality, repetitive courses of antenatal glucocorticoids are being …
distress syndrome and mortality, repetitive courses of antenatal glucocorticoids are being …
[引用][C] Evidence from multicenter neworks on the current use and effectiveness of antenatal corticosteroids in low birth weight infants
LL Wright, JD Horbar, H Gunkel, J Verter… - American journal of …, 1995 - Elsevier
Corticosteroid treatment of pregnant women at risk for preterm delivery enhances fetal lung
maturity and improves neonatal outcomes.'Despite convincing evidence of these effects, a …
maturity and improves neonatal outcomes.'Despite convincing evidence of these effects, a …
[HTML][HTML] Antenatal corticosteroids: a reappraisal of the drug formulation and dose
We review the history of antenatal corticosteroid therapy (ACS) and present recent
experimental data to demonstrate that this, one of the pillars of perinatal care, has been …
experimental data to demonstrate that this, one of the pillars of perinatal care, has been …