J. Clin. Invest. 108: 169–173 (2001). DOI: 10.1172/JCI200113530. terms of disaccharide
composition; the disaccharides are distinguished by the presence of variably sulfated or …

The structure of rat liver heparan sulfate (HS) has been investigated using a combination of
(a) chain scission with specific reagents,(b) disaccharide compositional analysis, and (c) …

Humans express seven heparan sulfate (HS) 3-O-sulfotransferases that differ in substrate
specificity and tissue expression. Although genetic studies have indicated that 3-O-sulfated …

Large numbers of proteins in animal tissues occur immobilized in the extracellular space, at
cell surfaces or in the extracellular matrix. Some are anchored through interactions with …

The glycosaminoglycan, heparan sulfate (HS) is composed of alternating units of hexuronic
acid and glucosamine, that are variously sulfate-substituted at different positions …

J. Clin. Invest. 108: 165–167 (2001). DOI: 10.1172/JCI200113560. away. Thus, heparan
sulfate could easily cross a fullthickness basement membrane and touch an adjacent cell …

J. Clin. Invest. 108: 175–180 (2001). DOI: 10.1172/JCI200113561. a molecular design in
which clusters of N-and O-sulfated sugar residues (red or green in Figure 1) are separated …

Antibodies against heparan sulfate (HS) are useful tools to study the structural diversity of
HS. They demonstrate the large sequential variation within HS and show the distribution of …

Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …

This overview attempts to cover, from a personal viewpoint, the development of the
'heparin'field during the last four decades. In particular, it emphasizes the metamorphosis of …