Experimental myocardial infarction was induced in rats. The myocardial accumulation of
hyaluronan (HA) and water during the development of infarction was measured. The …

Hyaluronidase has been shown to reduce the size of experimental myocardial infarcts and
to prevent the reduction in collateral coronary blood flow that normally occurs 15 minutes to …

A preliminary communication is presented on the intravenous injection of hyaluronidase in
acute myocardial infarction. Six cases are reported and electrocardiographic changes are …

By using biotin-labeled proteoglycan core protein, hyaluronan (hyaluronic acid; HA) was
visualized in rat heart grafts at different times (2, 4, and 6 d) after transplantation. In normal …

In an attempt to determine the mechanism by which hyaluronidase reduces myocardial
injury following coronary artery occlusion, myocardial blood flow was studied in 20 open …

The administration of hyaluronidase is a promising intervention to protect the ischemic
myocardium in man, but evidence of the extent to which it may reduce the ultimate size of an …

The effect of hyaluronidase on myocardial ischemic injury was examined in 13 patients with
acute myocardial infarction, and the results were compared with 11 patients who did not …

Ischemia in the isolated perfused rat heart resulted in an increase in coronary vascular
resistance. Studies were undertaken to determine the effect of hyaluronidase and …

To evaluate hyaluronidase's effect in reducing post-infarction myocardial necrosis, we
randomized 91 patients with anterior infarction to control (45) or to hyaluronidase-treatment …

Electrocardiographic, enzymatic, and morphologic signs of myocardial ischemic injury
following coronary occlusion have previously been shown to be ameliorated by reducing …