Model-informed drug development, pharmacokinetic/pharmacodynamic cutoff value determination, and antibacterial efficacy of benapenem against …
X Ji, F Xue, Z Kang, W Zhong, IH Kuan… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
Benapenem is a novel carbapenem. The objective of this study was to determine the
pharmacokinetic (PK)/pharmacodynamic (PD) cutoff values and evaluate the optimal …
pharmacokinetic (PK)/pharmacodynamic (PD) cutoff values and evaluate the optimal …
A first-in-human safety, tolerability, and pharmacokinetics study of benapenem in healthy Chinese volunteers
CY Zhao, Y Lv, Y Zhu, MJ Wei, MY Liu… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
The objective of this trial was to investigate the safety, tolerability, and pharmacokinetics
(PK) of benapenem administered by single or multiple intravenous infusions in healthy …
(PK) of benapenem administered by single or multiple intravenous infusions in healthy …
1565. Characterization of Tebipenem (SPR859) Pharmacokinetics–Pharmacodynamics (PK-PD) for Efficacy Against Enterobacteriaceae in a One-Compartment In …
BD VanScoy, NJ Onufrak, H Conde… - Open Forum …, 2019 - search.ebscohost.com
Background SPR859 (tebipenem) is the active form of the orally bioavailable prodrug
SPR994. Tebipenem is an oral carbapenem with a broad-spectrum activity against Gram …
SPR994. Tebipenem is an oral carbapenem with a broad-spectrum activity against Gram …
In vivo pharmacodynamics of β-lactams/nacubactam against carbapenem-resistant and/or carbapenemase-producing Enterobacter cloacae and Klebsiella …
M Hagihara, H Kato, T Sugano, H Okade, N Sato… - Antibiotics, 2021 - mdpi.com
Carbapenem-resistant Enterobacterales (CRE) and carbapenemase-producing
Enterobacterales (CPE) have become global threats. CRE− and CPE− derived infections …
Enterobacterales (CPE) have become global threats. CRE− and CPE− derived infections …
Pharmacokinetic-pharmacodynamic target attainment analysis of biapenem in adult patients: a dosing strategy
K Ikawa, N Morikawa, K Ikeda, H Ohge, T Sueda… - Chemotherapy, 2008 - karger.com
Background: A pharmacokinetic-pharmacodynamic (PK-PD) target attainment analysis to
build a dosing strategy for biapenem in adult patients has not been conducted. Methods: A …
build a dosing strategy for biapenem in adult patients has not been conducted. Methods: A …
Prediction of human pharmacokinetics of panipenem-betamipron, a new carbapenem, from animal data
A Kurihara, H Naganuma, M Hisaoka… - Antimicrobial agents …, 1992 - Am Soc Microbiol
The pharmacokinetic behavior of panipenem (PAPM)-betamipron (BP), a new carbapenem,
in humans was successfully predicted from data collected from six animal species. PAPM …
in humans was successfully predicted from data collected from six animal species. PAPM …
Pharmacokinetic-pharmacodynamic target attainment analyses as support for meropenem-vaborbactam dosing regimens and susceptibility breakpoints
SM Bhavnani, M Trang, DC Griffith… - Antimicrobial Agents …, 2022 - Am Soc Microbiol
Meropenem-vaborbactam is a fixed-dose beta-lactam/beta-lactamase inhibitor with potent in
vitro and in vivo activity against Klebsiella pneumoniae carbapenemase (KPC)-producing …
vitro and in vivo activity against Klebsiella pneumoniae carbapenemase (KPC)-producing …
A physiologically-based pharmacokinetic model for the antibiotic ertapenem
Ertapenem is an antibiotic commonly used to treat a broad spectrum of infections, which is
part of a broader class of antibiotics called carbapenem. Unlike other carbapenems …
part of a broader class of antibiotics called carbapenem. Unlike other carbapenems …
Pharmacodynamic evaluation of meropenem, cefepime, or aztreonam combined with a novel β-lactamase inhibitor, nacubactam, against carbapenem-resistant and/or …
M Hagihara, H Kato, T Sugano, H Okade, N Sato… - International Journal of …, 2021 - Elsevier
Abstract Background Carbapenem-resistant Enterobacterales (CRE) and carbapenemase-
producing Enterobacterales (CPE) are difficult to treat and are a serious public health threat …
producing Enterobacterales (CPE) are difficult to treat and are a serious public health threat …
Population pharmacokinetic analyses for tebipenem after oral administration of pro-drug tebipenem pivoxil hydrobromide
H Ganesan, VK Gupta, MC Safir… - Antimicrobial Agents …, 2023 - Am Soc Microbiol
Tebipenem pivoxil hydrobromide (TBP-PI-HBr) is an oral (PO) carbapenem pro-drug that is
converted to the active moiety tebipenem in the enterocytes. Tebipenem has activity against …
converted to the active moiety tebipenem in the enterocytes. Tebipenem has activity against …