The hepatocyte growth factor (HGF) and its receptor, the transmembrane tyrosine kinase
cMET, promote cell proliferation, survival, motility, and invasion as well as morphogenic …

MET is located on chromosome 7q31 and is a proto-oncogene that encodes for hepatocyte
growth factor (HGF) receptor, a member of the receptor tyrosine kinase (RTK) family. HGF …

Under normal physiological conditions, the hepatocyte growth factor (HGF) and its receptor,
the MET transmembrane tyrosine kinase (cMET), are involved in embryogenesis …

The hepatocyte growth factor (HGF)/c-Met signaling pathway is important in mediating a
wide range of biological activities, including embryological development, wound healing …

Receptor tyrosine kinases have come to fruition as therapeutic targets in a variety of
malignancies. In this group of targets, the c-Met receptor tyrosine kinase plays an important …

Hepatocellular carcinoma (HCC) is the fifth most common cancer and is the second leading
cause of cancer death. Since the diagnosis of HCC is difficult, in many cases patients with …

On binding to the cell surface receptor tyrosine kinase (TK) known as c-Met, hepatocyte
growth factor (HGF) stimulates mitogenesis, motogenesis, and morphogenesis in a wide …

Introduction: Under normal conditions, hepatocyte growth factor (HGF)-induced activation of
its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand …

The tumor microenvironment plays a key role in tumor development and progression.
Stromal cells secrete growth factors, cytokines and extracellular matrix proteins which …

The hepatocyte growth factor (HGF)–mesenchymal-epithelial transition factor (MET)
pathway has a key role in carcinogenesis; it is implicated in proliferation, inhibition of …