Efficacy and safety of spesolimab for the management of generalized pustular psoriasis: a drug safety evaluation

L Potestio, E Camela, S Cacciapuoti… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Generalized pustular psoriasis (GPP) is a rare form of psoriasis (less of 1% of
cases). Currently, GPP is recognized as a clinical entity, distinguished from plaque psoriasis …

Therapeutic Potential of Spesolimab-Sbzo in the Management of Generalized Pustular Psoriasis Flares in Adults: Evidence to Date

F Rega, F Trovato, G Bortone, G Pellacani… - … : Targets and Therapy, 2024 - Taylor & Francis
Generalized pustular psoriasis (GPP) is a rare, chronic, and severe skin disorder
characterized by the eruption of non-infectious pustules on an erythematous background …

[HTML][HTML] Design of Effisayil™ 2: a randomized, double-blind, placebo-controlled study of spesolimab in preventing flares in patients with generalized pustular psoriasis

A Morita, SE Choon, H Bachelez, MJ Anadkat… - Dermatology and …, 2023 - Springer
Introduction Generalized pustular psoriasis (GPP) is a rare autoinflammatory skin disease
characterized by flares of widespread erythema with sterile pustules, and can be relapsing …

Efficacy of spesolimab for the treatment of generalized pustular psoriasis flares across pre‐specified patient subgroups in the Effisayil 1 study

AD Burden, Y Okubo, M Zheng, D Thaçi… - Experimental …, 2023 - Wiley Online Library
Effisayil 1 was a multicentre, randomized, double‐blind, placebo‐controlled study of the anti‐
interleukin (IL)‐36 receptor monoclonal antibody, spesolimab, in patients presenting with a …

[HTML][HTML] Spesolimab for the treatment of generalized pustular psoriasis

D Bernardo, D Thaçi, T Torres - Drugs, 2024 - Springer
Generalized pustular psoriasis (GPP) is a rare but severe skin inflammatory disorder
characterized by the eruption of widespread sterile neutrophilic pustules, often accompanied …

Efficacy and safety of spesolimab in Asian patients with a generalized pustular psoriasis flare: Results from the randomized, double‐blind, placebo‐controlled Effisayil …

A Morita, TF Tsai, EYW Yee, Y Okubo… - The Journal of …, 2023 - Wiley Online Library
Generalized pustular psoriasis is a potentially life‐threatening neutrophilic skin disease
characterized by recurrent flares of widespread erythema and eruption of sterile pustules. In …

Exploring the clinical assessment, guidelines, and options for the treatment of generalized pustular psoriasis [podcast]

EJ Song, C Liu - Clinical, Cosmetic and Investigational …, 2023 - Taylor & Francis
Acute episodes of generalized pustular psoriasis (GPP), known as “flares”, are characterized
by the widespread appearance of pustules with surrounding skin erythema, and are often …

Use of biological therapies for the management of pustular psoriasis: a new era?

M Megna, E Camela, A Ruggiero… - Clinical, cosmetic and …, 2023 - Taylor & Francis
Generalized pustular psoriasis (GPP) is a severe and rare form of psoriasis, being a
potentially life-threatening condition, characterized by recurring episodes or flares of …

Spesolimab treatment in a patient with generalized pustular psoriasis: a case report with 12-month follow-up and literature review

JA Cardenas-de la Garza… - Clinical and …, 2024 - academic.oup.com
This article explores the use of spesolimab in generalized pustular psoriasis (GPP) and
presents the case of a Hispanic patient with GPP and plaque psoriasis treated with …

[HTML][HTML] Trial of spesolimab for generalized pustular psoriasis

H Bachelez, SE Choon, S Marrakchi… - … England Journal of …, 2021 - Mass Medical Soc
Background Generalized pustular psoriasis (GPP) is a rare, life-threatening, inflammatory
skin disease characterized by widespread eruption of sterile pustules. Interleukin-36 …