The regulation of aromatase, an enzyme involved in the biosynthesis of estrogen in normal
and cancer cells, has been associated with growth factor signaling and immune response …

Estrogen signaling has been implicated in hormone-dependent breast cancer which
constitutes> 75% of breast cancer diagnosis and other malignancies. Aromatase, the key …

Aromatase is the rate-limiting enzyme in the biosynthesis of estrogens, which play crucial
roles on a spectrum of developmental and physiological processes. The biological actions of …

A single gene encodes the key enzyme for estrogen biosynthesis termed aromatase,
inhibition of which effectively eliminates estrogen production. Aromatase inhibitors …

The development of the novel “third generation” aromatase inhibitors (anastrozole, letrozole)
and inactivators (exemestane) is one of the most successful contemporary achievements in …

Long-term exposure to excess estrogen increases the risk of breast cancer and type 1
endometrial cancer. Most of the estrogen in premenopausal women is synthesized by the …

Estrogen and its cognate estrogen receptor are key players in the etiology and progression
of breast cancer. Aromatase inhibitors, suppressing tumor and plasma estrogen levels by …

By converting androstenedione to estrone, or testosterone to estradiol, aromatase is a key
enzyme in estrogen biosynthesis. Encoded by a single gene CYP19, aromatase is …

Aromatase is the rate limiting enzyme that catalyzes the conversion of androgens to
estrogens. Blockade of this step allows treatment of diseases that are dependent upon …

The current therapeutic approach for the treatment of hormone dependent breast cancer
includes interference with estrogen receptors via either selective modulators or estrogens …