The anti-diabetic potential of baicalin: evidence from rodent studies

T Szkudelski, K Szkudelska - International Journal of Molecular Sciences, 2023 - mdpi.com
Baicalin is a biologically active flavonoid compound that benefits the organism in various
pathological conditions. Rodent studies have shown that this compound effectively …

Baicalin: A potential therapeutic agent for diabetes and renal protection

LRP Louis, P Nagarajan, P Muthiah… - Bioactive Compounds in …, 2023 - ffhdj.com
Background: Diabetes is a complex metabolic disease manifested by raised glucose levels
in the blood and impaired insulin function leading to various organ complications, including …

Baicalin and its aglycone: a novel approach for treatment of metabolic disorders

P Fang, M Yu, M Shi, P Bo, X Gu, Z Zhang - Pharmacological Reports, 2020 - Springer
Background The current strategies for prevention and treatment of insulin resistance and
type 2 diabetes are not fully effective and frequently accompanied by many negative effects …

[HTML][HTML] Baicalin ameliorates insulin resistance and regulates hepatic glucose metabolism via activating insulin signaling pathway in obese pre-diabetic mice

L Miao, X Zhang, H Zhang, MS Cheong, X Chen… - Phytomedicine, 2024 - Elsevier
Background Diabetes belongs to the most prevalent metabolic diseases worldwide, which is
featured with insulin resistance, closely associated with obesity and urgently needs to be …

Baicalin ameliorates hepatic insulin resistance and gluconeogenic activity through inhibition of p38 MAPK/PGC-1α pathway

P Fang, Y Sun, X Gu, M Shi, P Bo, Z Zhang, L Bu - Phytomedicine, 2019 - Elsevier
Background Although the results of our and other studies show that baicalin can enhance
glucose uptake and insulin sensitivity in skeletal muscle and adipocytes of mice, the specific …

Baicalin and its metabolites suppresses gluconeogenesis through activation of AMPK or AKT in insulin resistant HepG-2 cells

T Wang, H Jiang, S Cao, Q Chen, M Cui, Z Wang… - European Journal of …, 2017 - Elsevier
Scutellaria baicalensis Georgi (S. baicalensis), as a traditional Chinese herbal medicine, is
an important component of several famous Chinese medicinal formulas for treating patients …

Beneficial effect of baicalin on insulin sensitivity in adipocytes of diet-induced obese mice

P Fang, M Yu, W Min, S Han, M Shi, Z Zhang… - Diabetes research and …, 2018 - Elsevier
Aims Although baicalin has been shown to increase glucose uptake and insulin sensitivity in
skeletal muscle of mice, there is no literature available about the effect of baicalin on insulin …

Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway

P Fang, M Yu, L Zhang, D Wan, M Shi, Y Zhu… - Molecular and cellular …, 2017 - Elsevier
Obesity may cause several metabolic complications, including insulin resistance and type 2
diabetes mellitus. Despite great advances in medicine, people still keep exploring novel and …

Baicalin protects against insulin resistance and metabolic dysfunction through activation of GALR2/GLUT4 signaling

M Yu, S Han, M Wang, L Han, Y Huang, P Bo, P Fang… - Phytomedicine, 2022 - Elsevier
Background Type 2 diabetes mellitus is a complex metabolic disorder associated with
obesity, glucose intolerance and insulin resistance. Activation of GALR2 has been proposed …

Antihyperglycemic effects of baicalin on streptozotocin–nicotinamide induced diabetic rats

HT Li, XD Wu, AK Davey, J Wang - Phytotherapy Research, 2011 - Wiley Online Library
The aim of the study was to investigate the effects of baicalin on blood glucose, insulin and
cytokine levels. Rat diabetes was induced by intraperitoneal (ip) injection of nicotinamide …