The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

Background: Formation of new blood vessels, by either angiogenesis or vasculogenesis, is
critical for normal wound healing. Major processes in neovascularization include (i) growth …

The Role of Therapeutic Angiogenesis in Tissue Repair and Regeneration Page 1 The Role
of Therapeutic Angiogenesis in Tissue Repair and Regeneration William W. Li, MD & …

Significance: Revascularization plays a critical role in wound healing and is regulated by a
complex milieu of growth factors and cytokines. Deficiencies in revascularization contribute …

Highlights•Neovascularization plays a critical role in wound healing impacting the quality of
neotissue formation.•Biomaterial-based approaches can improve angiogenesis …

Skin injuries and in particular, chronic wounds, are one of the major prevalent medical
problems, worldwide. Due to the pivotal role of angiogenesis in tissue regeneration …

Significance: Re-establishment of a functional vascular network is a critical component of
successful wound repair. One of the most potent pro-angiogenic agents is vascular …

A key central stage of wound healing requires neovascularization of the wound base
granulation tissue. In the adult, neovascularization is now known to occur by both …

Normal tissue function requires adequate supply of oxygen through blood vessels.
Understanding how blood vessels form is a challenging objective because angiogenesis is …

Angiogenesis, or the growth of new blood vessels from the preexisting vasculature, is a
visible and important component of wound repair. When tissue damage occurs, disruption of …