Despite decades of research on neurobiological mechanisms of psychostimulant addiction,
the only effective treatment for many addicts is contingency management, a behavioral …

Rationale Recent studies have attempted to identify the neuroanatomical substrates
underlying primed reinstatement of drug-seeking behavior. Identification of neuronal …

We recently introduced an animal model to study incubation of drug craving after prolonged
voluntary abstinence, mimicking the human condition of relapse after successful …

Studies using the renewal procedure showed that basolateral amygdala (BLA) inactivation
inhibits context-induced relapse to cocaine-seeking after extinction. Here, we determined …

We recently reported that social choice-induced voluntary abstinence prevents incubation of
methamphetamine craving in rats. This inhibitory effect was associated with activation of …

Contexts exert bi-directional control over relapse to drug seeking. Contexts associated with
drug self-administration promote relapse, whereas contexts associated with the absence of …

Drug addiction is characterized by persistent relapse vulnerability during abstinence. In
abstinent drug users, relapse is often precipitated by re-exposure to environmental contexts …

Relapse to drug use following abstinence is a significant impediment in the long-term
treatment of drug abuse and dependence. Conditioned stimuli are believed to be critically …

Drug seeking behavior can be reduced or inhibited via extinction. The brain mechanisms for
extinction of drug seeking are poorly understood but are of significant interest because of …

Extinction is the reduction in drug seeking when the contingency between drug seeking
behavior and the delivery of drug reward is broken. Here, we investigated a role for the …