Role of hypothalamic neuropeptide Y in feeding and obesity

DR Gehlert - Neuropeptides, 1999 - Elsevier
The 36-amino-acid peptide, neuropeptide Y (NPY), is the most abundant peptide in the rat
brain. When administered into the brain, NPY produces a variety of physiological actions …

Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype

RE Campbell, MA Cowley, MS Smith, KL Grove - Neuroendocrinology, 2001 - karger.com
Neuropeptide Y (NPY) displays diverse modes of action in the CNS including the
modulation of feeding behavior, gonadotropin releasing hormone release, and stress …

Neuropeptide Y chronically injected into the hypothalamus: a powerful neurochemical inducer of hyperphagia and obesity

BG Stanley, SE Kyrkouli, S Lampert, SF Leibowitz - Peptides, 1986 - Elsevier
Neuropeptide Y (NPY), a putative neurotransmitter abundant in the brain, has recently been
shown to act within the hypothalamus, inducing a powerful eating response and a specific …

Potent neuropeptide Y Y1 receptor antagonist, 1229U91: blockade of neuropeptide Y-induced and physiological food intake

A Kanatani, A Ishihara, S Asahi, T Tanaka… - …, 1996 - academic.oup.com
Neuropeptide Y (NPY) is thought to increase food intake through the action of Y1 (-like)
receptors in the hypothalamus. To confirm the involvement of Y1 receptors in feeding …

Increased neuropeptide Y content in individual hypothalamic nuclei, but not neuropeptide Y mRNA, in diet-induced obesity in rats

JPH Wilding, SG Gilbey, M Mannan… - Journal of …, 1992 - joe.bioscientifica.com
Neuropeptide Y (NPY) is the most powerful appetite stimulant known, and chronic
administration leads to obesity. The hypothalamic content of NPY varies with nutritional …

Neuropeptide Y in normal eating and in genetic and dietary-induced obesity

B Beck - Philosophical Transactions of the Royal Society …, 2006 - royalsocietypublishing.org
Neuropeptide Y (NPY) is one the most potent orexigenic peptides found in the brain. It
stimulates food intake with a preferential effect on carbohydrate intake. It decreases latency …

Neuropeptide Y-related peptides and their receptors: are the receptors potential therapeutic drug targets?

C Wahlestedt, DJ Reis - Annual review of pharmacology and …, 1993 - psycnet.apa.org
Focuses on functional aspects of neuropeptide Y (NPY) that may set it apart from many other
neurohormonal peptides that have been investigated in recent decades. NPY has been …

Neuropeptide y receptor selective ligands in the treatment of obesity

MM Kamiji, A Inui - Endocrine reviews, 2007 - academic.oup.com
Obesity is a serious public health problem throughout the world, affecting both developed
societies and developing countries. The central nervous system has developed a …

Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior

Y Hu, BT Bloomquist, LJ Cornfield, LB DeCarr… - Journal of Biological …, 1996 - ASBMB
Neuropeptide Y (NPY) plays important roles in the central control of appetite and energy
balance, but the receptor subtype responsible for this function has not been cloned. Here we …

Hormonal control of the neuropeptide Y system

P Magni - Current Protein and Peptide Science, 2003 - ingentaconnect.com
Neuropeptide Y (NPY) and the related receptors represent a widely diffused system that is
involved in the regulation of multiple biological functions. NPY, a 36-aminoacid peptide …