Within one minute of acute coronary artery occlusion in the isolated rat heart performing
external mechanical work, cardiac output and left ventricular peak systolic pressure fell by …

AUTHORS'SYNOPSIS The long-term effects of left coronary artery occlusion were studied
on the metabolism and function of the isolated, perfused rat heart. Metabolic studies …

The purpose of the study was to assess the ability of the calcium channel blocker diltiazem
to limit infarct size in rat. Myocardial infarct size was measured by planimetry of histologic …

Ischemia was induced by lowering the after-load pressure of the perfused working rat heart,
and continued until the heart was reperfused by raising the after-load. After ischemia, the …

Since isoproterenol, tachycardia induced by atrial pacing, propranolol and Hyaluronidase
alter the extent and severity of cardiac damage after coronary occlusion, their effects on the …

The effects on myocardial function, metabolism and ultrastructure of 60 minutes of
reperfusion, instituted after 30, 60 and 90 minutes of occlusion of the left anterior descending …

Diltiazem-HCl,® a potent calcium channel blocker, was found to be effective in moderating
the harmful effects of reperfusion on the severely ischemic myocardium. In isolated working …

The effects of coronary artery occlusion and reperfusion at 1 hour (1-hr group), 2 hours (2-hr
group), and 3 hours (3-hr group) were compared with a permanently occluded group (P …

Myocardial ischemia causes both systolic and diastolic dysfunction. A variety of positive
inotropic agents with different subcellular mechanisms may be used clinically in an attempt …

Myocardial infarction was induced in rats by ligation of the descending branch of the left
coronary artery. The time course of changes in heart function was recorded within the first …