Objectives The impact of inhaled corticosteroids (ICS) on eosinophilic inflammation in
asthma is well established, but their effect in a real-life setting has not been extensively …

Background It is unclear whether patients with asthma benefit from stepping up to high-dose
inhaled corticosteroids (ICSs). Objective To determine the effectiveness of stepping up to …

Introduction: Systemic corticosteroids (SCS) are effective anti-inflammatory therapies for
patients with severe or persistent asthma. Use of SCS reduces blood eosinophil counts; the …

Objective: To determine the effects of smoking on efficacy of inhaled corticosteroids in
asthmatics. Research design and methods: Prospective/retrospective, controlled studies …

Background While non‐eosinophilic asthmatics are usually considered poorly responsive to
inhaled corticosteroids (ICS s), studies assessing a step‐down of ICS in this specific …

Background Asthma is characterized by chronic airway inflammation, and inhaled
corticosteroids (ICSs) have been recommended as first-line treatment. However, response to …

BACKGROUND: Although inhaled corticosteroids (ICSs) are effective in preventing
deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will …

Objective To provide an overview of the risk factors and mechanisms underlying asthma
exacerbations and the role of inhaled corticosteroids (ICSs) in preventing exacerbations …

Background Severe asthma (SA) may require frequent courses or chronic use of oral
corticosteroids (OCS), inducing many known side effects and complications. Therefore, it is …

Background It has been suggested that smoking asthmatics benefit less from corticosteroid
treatment than never-smoking asthmatics. We investigated differences in blood and sputum …