Implantable Cardiovascular Therapeutic Devices (CTD), while lifesaving, impart
supraphysiologic shear stress to platelets, resulting in thrombotic and bleeding …

Background Implantable cardiovascular therapeutic devices, while hemodynamically
effective, remain limited by thrombosis. A driver of device-associated thrombosis is shear …

Objective: Mechanical circulatory support has emerged as lifesaving therapy for patients
with advanced heart failure. However, mechanical circulatory support remains limited by a …

Disturbances of blood flow at sites of atherosclerotic plaque rupture are one of the key
pathogenic events promoting platelet activation and arterial thrombus formation. Shear …

We systematically analyzed the relative contributions of frequency component elements of
hemodynamic shear stress waveforms encountered in cardiovascular blood recirculating …

After exposure to an agonist, platelets are activated and become aggregated. They also
shed membrane microparticles that participate in the pathogenesis of thrombosis, hyper …

This study aimed to examine the mechanisms of cellular activation by small‐size platelet
microparticles (sPMP) and to present the performance of high‐resolution flow cytometry for …

MPs enhance the deposition of platelets and fibrin to the injured or atherosclerotic arterial
vessel wall. MPs may also bind to already adhered platelets under high shear rate …

Microparticles released from platelets (PMPs) may play a role in the normal hemostatic
response to vascular injury because they demonstrate prothrombinase activity. PMPs were …

Platelet microparticles (PMPs) are released from activated platelets and express functional
adhesion receptors, including P-selectin, on their surface. PMP concentrations are elevated …