A mesenchymal stem cell (MSC)-seeded collagen gel under static or dynamic tension is a
well-established model to study the potential of MSCs in regenerating a tendon-or ligament …

Tendons are force transmitting mechanosensitive tissues predominantly comprised of highly
aligned collagen type I fibres. In this study, the recently introduced gel aspiration-ejection …

Extracellular matrix modulus plays an important role in regulating cell morphology,
proliferation and differentiation during regular and diseased states. Although the effects of …

Tendon and ligament pathologies are still a therapeutic challenge, due to the difficulty in
restoring the complex extracellular matrix architecture and biomechanical strength. While …

Mesenchymal stem cells (MSCs) have potential applications in regenerative medicine and
tissue engineering and may represent an attractive option for tendon repair and …

We investigated substrate dependent paracrine signaling between subpopulations of bone
marrow stromal cells (BMSCs) that may affect the formation, or perhaps malformation, of the …

Topographical cell guidance has been utilized as a tissue-engineering technique to produce
aligned cellular orientation in the regeneration of tendon-and ligament-like tissues. Other …

To inform future efforts in tendon/ligament tissue engineering, our laboratory has developed
a well-controlled model system with the ability to alter both external tensile loading …

Following tendon injury, cartilage, bone and fat metaplasia are often observed, making the
optimization of tenocyte differentiation an important clinical goal. In this study we examined …

Substrates with mechanical property gradients and various extracellular matrix ligand
loadings were evaluated for their ability to direct bone marrow stromal cell differentiation …