The epigenome is a dynamic system of chemical modifications that operate to control
chromatin structure and regulate gene activity without altering the underlying DNA …

During ageing, the human methylome exhibits both differential (ie change in mean) and
variable (ie change in variance) shifts, along with a general rise in entropy. However, it …

Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …

DNA methylation plays an important role in development of disease and the process of
aging. In this study we examine DNA methylation at 476,366 sites throughout the genome of …

The ability to measure human aging from molecular profiles has practical implications in
many fields, including disease prevention and treatment, forensics, and extension of life …

During ageing, the human methylome exhibits both differential (ie change in mean) and
variable (ie change in variance) shifts, along with a general rise in entropy. However, it …

Background DNA methylation is an epigenetic modification that changes with age in human
tissues, although the mechanisms and specificity of this process are still poorly understood …

Differences in DNA methylation patterns have been observed among individuals of
disparate ages in both a tissue-dependent manner and tissue-independent manner. In …

Methylation is a ubiquitous, naturally occurring biochemical modification of DNA in
mammalian cells that regulates gene expression. DNA methylation patterns are generally …

Aging is a physiological process and represents one of the major risk factors for various
human diseases, such as cancer, cardiovascular diseases and most neurodegenerative …