[HTML][HTML] Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in …
Aberrant glucocorticoid signaling via glucocorticoid receptors (GR) plays a critical role in
alcohol use disorder (AUD). Acute alcohol withdrawal and protracted abstinence in …
alcohol use disorder (AUD). Acute alcohol withdrawal and protracted abstinence in …
[HTML][HTML] Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats
Impairments in the function of the hypothalamic-pituitary-adrenal (HPA) axis and enhanced
glucocorticoid receptor (GR) activity in the central amygdala (CeA) are critical mechanisms …
glucocorticoid receptor (GR) activity in the central amygdala (CeA) are critical mechanisms …
Glucocorticoid receptor modulators decrease alcohol self-administration in male rats
Alcohol use disorder (AUD) is associated with the dysregulation of brain stress and reward
systems, including glucocorticoid receptors (GRs). The mixed glucocorticoid/progesterone …
systems, including glucocorticoid receptors (GRs). The mixed glucocorticoid/progesterone …
Corticotropin releasing factor–induced amygdala gamma-aminobutyric acid release plays a key role in alcohol dependence
BACKGROUND: Corticotropin-releasing factor (CRF) and gamma-aminobutyric acid (GABA)
ergic systems in the central amygdala (CeA) are implicated in the high-anxiety, high-drinking …
ergic systems in the central amygdala (CeA) are implicated in the high-anxiety, high-drinking …
Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
LF Vendruscolo, D Estey, V Goodell… - The Journal of …, 2015 - Am Soc Clin Investig
Alcoholism, or alcohol use disorder, is a major public health concern that is a considerable
risk factor for morbidity and disability; therefore, effective treatments are urgently needed …
risk factor for morbidity and disability; therefore, effective treatments are urgently needed …
Alcohol dependence induces CRF sensitivity in female central amygdala GABA synapses
Alcohol use disorder (AUD) is a chronically relapsing disease characterized by loss of
control in seeking and consuming alcohol (ethanol) driven by the recruitment of brain stress …
control in seeking and consuming alcohol (ethanol) driven by the recruitment of brain stress …
Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats
Alcoholism is characterized by a compulsion to seek and ingest alcohol, loss of control over
intake, and the emergence of a negative emotional state during abstinence. We …
intake, and the emergence of a negative emotional state during abstinence. We …
Chronic ethanol consumption alters glucocorticoid receptor isoform expression in stress neurocircuits and mesocorticolimbic brain regions of alcohol-preferring rats
Evidence suggests the hypothalamic–pituitary–adrenal (HPA) axis is involved in Alcohol
Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor …
Use Disorders (AUDs), which might be mediated by an imbalance of glucocorticoid receptor …
A functional switch in tonic GABA currents alters the output of central amygdala corticotropin releasing factor receptor-1 neurons following chronic ethanol exposure
The corticotropin releasing factor (CRF) system in the central amygdala (CeA) has been
implicated in the effects of acute ethanol and the development of alcohol dependence. We …
implicated in the effects of acute ethanol and the development of alcohol dependence. We …
Corticotropin releasing factor signaling in the central amygdala is recruited during binge-like ethanol consumption in C57BL/6J mice
EG Lowery-Gionta, M Navarro, C Li… - Journal of …, 2012 - Soc Neuroscience
A well established body of work indicates a crucial role for corticotropin-releasing factor
(CRF) in neurobiological responses associated with excessive dependence-like ethanol …
(CRF) in neurobiological responses associated with excessive dependence-like ethanol …