Use of polymeric nanoparticle platform targeting the liver to induce treg-mediated antigen-specific immune tolerance in a pulmonary allergen sensitization model
Nanoparticles (NPs) can be used to accomplish antigen-specific immune tolerance in
allergic and autoimmune disease. The available options for custom-designing tolerogenic …
allergic and autoimmune disease. The available options for custom-designing tolerogenic …
Antigen-and epitope-delivering nanoparticles targeting liver induce comparable immunotolerance in allergic airway disease and anaphylaxis as nanoparticle …
The targeting of natural tolerogenic liver sinusoidal endothelial cells (LSEC) by
nanoparticles (NPs), decorated with a stabilin receptor ligand, is capable of generating …
nanoparticles (NPs), decorated with a stabilin receptor ligand, is capable of generating …
Biodegradable antigen-associated PLG nanoparticles tolerize Th2-mediated allergic airway inflammation pre-and postsensitization
CB Smarr, WT Yap, TP Neef… - Proceedings of the …, 2016 - National Acad Sciences
Specific immunotherapy (SIT) is the most widely used treatment for allergic diseases that
directly targets the T helper 2 (Th2) bias underlying allergy. However, the most widespread …
directly targets the T helper 2 (Th2) bias underlying allergy. However, the most widespread …
An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy
DP McCarthy, JWT Yap, CT Harp, WK Song… - … , Biology and Medicine, 2017 - Elsevier
Tolerogenic nanoparticles (NPs) are rapidly being developed as specific immunotherapies
to treat autoimmune disease. However, many NP-based therapies conjugate antigen (Ag) …
to treat autoimmune disease. However, many NP-based therapies conjugate antigen (Ag) …
Prevention of allergy by virus‐like nanoparticles (VNP) delivering shielded versions of major allergens in a humanized murine allergy model
B Kratzer, C Köhler, S Hofer, U Smole, D Trapin… - Allergy, 2019 - Wiley Online Library
Background In high‐risk populations, allergen‐specific prophylaxis could protect from
sensitization and subsequent development of allergic disease. However, such treatment …
sensitization and subsequent development of allergic disease. However, such treatment …
PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance
The development of nanomaterials to induce antigen-specific immune tolerance has shown
promise for treating autoimmune diseases. While PEGylation has been widely used to …
promise for treating autoimmune diseases. While PEGylation has been widely used to …
Use of a liver-targeting immune-tolerogenic mRNA lipid nanoparticle platform to treat peanut-induced anaphylaxis by single-and multiple-epitope nucleotide …
While oral desensitization is capable of alleviating peanut allergen anaphylaxis, long-term
immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle …
immune tolerance is the sought-after goal. We developed a liver-targeting lipid nanoparticle …
[HTML][HTML] Nanotechnology-based vaccines for allergen-specific immunotherapy: Potentials and challenges of conventional and novel adjuvants under research
The increasing prevalence of allergic diseases demands efficient therapeutic strategies for
their mitigation. Allergen-specific immunotherapy (AIT) is the only causal rather than …
their mitigation. Allergen-specific immunotherapy (AIT) is the only causal rather than …
Tackling autoimmunity with nanomedicines
X Feng, J Liu, W Xu, G Li, J Ding - Nanomedicine, 2020 - Taylor & Francis
Tolerogenic immunotherapy aims to blunt pathogenic inflammation without affecting
systemic immunity. However, the anti-inflammatory drugs and immunosuppressive biologics …
systemic immunity. However, the anti-inflammatory drugs and immunosuppressive biologics …
Improved vaccine-induced immune responses via a ROS-triggered nanoparticle-based antigen delivery system
X Liang, J Duan, X Li, X Zhu, Y Chen, X Wang, H Sun… - Nanoscale, 2018 - pubs.rsc.org
Subunit vaccines that are designed based on recombinant antigens or peptides have shown
promising potential as viable substitutes for traditional vaccines due to their better safety and …
promising potential as viable substitutes for traditional vaccines due to their better safety and …