The muscular dystrophies are a group of heterogeneous genetic diseases characterized by
progressive degeneration and weakness of skeletal muscle. Since the discovery of the first …

Muscular dystrophies are a genetically heterogeneous group of degenerative muscle
disorders. Nearly 30 genes are known to give rise to various forms of muscular dystrophy …

Neuromuscular disorders comprise a diverse group of human inborn diseases that arise
from defects in the structure and/or function of the muscle tissue—encompassing the muscle …

Current molecular genomic approaches to human genetic disorders have led to an
explosion in the identification of the genes and their encoded proteins responsible for these …

The study of the muscle cell in the muscular dystrophies (MDs) has shown that mutant
proteins result in perturbations of many cellular components. MDs have been associated …

We used expression profiling to define the pathophysiological cascades involved in the
progression of two muscular dystrophies with known primary biochemical defects …

Muscular dystrophy is a group of more than 30 different clinical genetic disorders that are
characterized by progressive skeletal muscle wasting and degeneration. Primary deficiency …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

Although dystrophin mutations are the proximate cause of Duchenne muscular dystrophy
(DMD), interactions among heterogeneous downstream mechanisms may be key …

Muscular dystrophies are a group of diseases that primarily affect skeletal muscle and are
characterized by progressive muscle wasting and weakness. Although these diseases have …