Neuroplasticity and multilevel system of connections determine the integrative role of nucleus accumbens in the brain reward system

M Bayassi-Jakowicka, G Lietzau, E Czuba… - International Journal of …, 2021 - mdpi.com
A growing body of evidence suggests that nucleus accumbens (NAc) plays a significant role
not only in the physiological processes associated with reward and satisfaction but also in …

More than addiction—the nucleus accumbens contribution to development of mental disorders and neurodegenerative diseases

M Bayassi-Jakowicka, G Lietzau, E Czuba… - International Journal of …, 2022 - mdpi.com
Stress and negative emotions evoked by social relationships and working conditions,
frequently accompanied by the consumption of addictive substances, and metabolic and/or …

[PDF][PDF] Distinct reward processing by subregions of the nucleus accumbens

G Chen, S Lai, G Bao, J Ke, X Meng, S Lu, X Wu, H Xu… - Cell Reports, 2023 - cell.com
The nucleus accumbens (NAc) plays an important role in motivation and reward processing.
Recent studies suggest that different NAc subnuclei differentially contribute to reward …

Neural integrative activities of nucleus accumbens subregions in relation to learning and motivation

AE Kelley - Psychobiology, 1999 - Springer
In recent years, there has been much interest in the functional specializations of nucleus
accumbens subregions. The two zones within the nucleus accumbens that have received …

Neural mechanisms of the nucleus accumbens circuit in reward and aversive learning

T Hikida, M Morita, T Macpherson - Neuroscience research, 2016 - Elsevier
The basal ganglia are key neural substrates not only for motor function, but also cognitive
functions including reward and aversive learning. Critical for these processes are the …

Nucleus accumbens modulation in reward and aversion

AM Klawonn, RC Malenka - Cold Spring Harbor symposia on …, 2018 - symposium.cshlp.org
The nucleus accumbens (NAc) is a key node of the brain's circuitry that is responsible for
translating motivation into action. It has been implicated in playing critical roles in virtually all …

The role of the nucleus accumbens in psychiatric disorders

I Mavridis - Psychiatrike= Psychiatriki, 2015 - europepmc.org
The nucleus accumbens is the most inferior part of the striatum and is mainly connected to
the limbic system. It is neurochemically and immunohistochemically divided into a shell …

Molecular plasticity of the nucleus accumbens revisited—astrocytic waves shall rise

J Kardos, Á Dobolyi, Z Szabó, Á Simon, G Lourmet… - Molecular …, 2019 - Springer
Part of the ventral striatal division, the nucleus accumbens (NAc) drives the circuit activity of
an entire macrosystem about reward like a “flagship,” signaling and leading diverse …

Role of nucleus accumbens glutamatergic plasticity in drug addiction

GC Quintero - Neuropsychiatric disease and treatment, 2013 - Taylor & Francis
Substance dependence is characterized by a group of symptoms, according to the
Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV …

Pathway-specific modulation of nucleus accumbens in reward and aversive behavior via selective transmitter receptors

T Hikida, S Yawata, T Yamaguchi… - Proceedings of the …, 2013 - National Acad Sciences
The basal ganglia–thalamocortical circuitry plays a central role in selecting actions that
achieve reward-seeking outcomes and avoid aversive ones. Inputs of the nucleus …