Uromodulin is the most abundant protein in the urine. It is exclusively produced by renal
epithelial cells and it plays key roles in kidney function and disease. Uromodulin mainly …

Uromodulin is the most abundant protein secreted in urine, in which it is found as a high-
molecular-weight polymer. Polymerization occurs via its zona pellucida (ZP) domain, a …

Uromodulin (or Tamm–Horsfall protein) is the most abundant protein in human urine under
physiological conditions. Little is known about the molecular mechanism of uromodulin …

Uromodulin (UMOD)/Tamm–Horsfall protein, the most abundant human urinary protein,
plays a key role in chronic kidney diseases and is a promising therapeutic target for …

Assembly of extracellular filaments and matrices mediating fundamental biological
processes such as morphogenesis, hearing, fertilization, and antibacterial defense is driven …

Uromodulin (or Tamm-Horsfall protein) is a glycoprotein uniquely produced in the kidney by
tubular cells of the thick ascending limb of the loop of Henle and early distal tubules. This …

Uromodulin is the most abundant urinary protein in physiological conditions. It is exclusively
produced by renal epithelial cells lining the thick ascending limb of Henle's loop (TAL) and it …

Medullary cystic kidney disease/familial juvenile hyperuricemic nephropathy (MCKD/FJHN)
are autosomal dominant renal disorders characterized by tubulo‐interstitial fibrosis …

Biology has taught us that a protein as abundantly made and conserved among species as
Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no …

The glycoprotein uromodulin (UMOD) is the most abundant protein in human urine and
forms filamentous homopolymers that encapsulate and aggregate uropathogens, promoting …