Radiation therapy induces DNA damage and inflammation leading to fibrosis. Fibrosis can
occur 4 to 12 months after radiation therapy. This process worsens with time and years …

Significance: This review evaluates the role of platelet-derived transforming growth factor
(TGF)-β1 in oxidative stress-linked pathologic fibrosis, with an emphasis on the heart and …

Transforming growth factor beta (TGF-β) plays key roles in regulating cellular proliferation
and maintaining tissue homeostasis. TGF-β exerts tumor-suppressive effects in the early …

Inflammation and oxidative stress are common and co-substantial pathological processes
accompanying, promoting, and even initiating numerous cancers. The canonical WNT/β …

Emerging evidences show that changes in tumor stroma can adapt cancer cells to
radiotherapy, thereby leading to a reduction in tumor response to treatment. On the other …

Deregulation of normal regenerative responses to physical, chemical and biological toxins
in susceptible individuals leads to abnormal remodelling of extracellular matrix with …

Radiation‐induced lung injury (RILI) mainly contributes to the complications of thoracic
radiotherapy. RILI can be divided into radiation pneumonia (RP) and radiation‐induced lung …

Radiotherapy or accidental exposure to high-dose radiation can cause severe damage to
healthy organs. The gastrointestinal (GI) tract is a radiation-sensitive organ of the body. The …

Purpose: Radiotherapy is used for the treatment of lung cancer, but at the same time induces
acute pneumonitis and subsequent pulmonary fibrosis, where TGF-β signaling is considered …

Radiation-induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …