Osteoarthritis, a highly age‐related and chronic inflammatory disorder with cartilage loss,
causes patients difficultly in movement; there is no efficient and sustainable remedy for …

Sustained and controllable local gene therapy is a potential method for treating osteoarthritis
(OA) through the delivery of therapeutic microRNAs (miRNAs) to targeted cells. However …

The interior environment of articular cartilage in osteoarthritis (OA) presents substantial
hurdles, leading to the malfunction of chondrocytes and the breakdown of collagen II …

Background The previous studies indicated that CrmA could ameliorate the interleukin-1β
induced osteoarthritis. In this study, we investigated the controlled-released cytokine …

Autophagy is a protective mechanism in normal cartilage. The present study aimed to
investigate the synergistic therapeutic effect of promotion of chondrocyte autophagy via …

Intra-articular injection of mesenchymal stem cells is a potential therapeutic strategy for
cartilage protection and symptoms relief of osteoarthritis (OA). However, controlling …

Osteoarthritis is a debilitating, progressive joint disease linked to lower quality of life and
higher health care costs. This study compared hyaluronic acid-chitosan nanoparticle …

Subcellular mitochondria serve as sensors for energy metabolism and redox balance, and
the dynamic regulation of functional and dysfunctional mitochondria plays a crucial role in …

This study uses the knee Osteoarthritis (OA) rat (constructed by the anterior cruciate
ligament transection) and the inflammatory chondrocyte (constructed by 20 ng mL− 1 tumor …

Background: Pain and cartilage destruction caused by osteoarthritis (OA) is a major
challenge in clinical treatment. Traditional intra-articular injection of hyaluronic acid (HA) can …