Chronic neuropathic pain is a debilitating ordeal for patients worldwide and
pharmacological treatment efficacy is still limited. As many pharmacological interventions for …

Descending brainstem control of spinal nociceptive processing permits a dynamic and
adaptive modulation of ascending sensory information. Chronic pain states are frequently …

The rostroventromedial medulla (RVM) is an important source of descending modulatory
systems that both inhibit and facilitate pain at the level of the spinal cord. Noxious stimuli can …

Chronic primary pain (CPP) is a group of diseases with long‐term pain and functional
disorders but without structural or specific tissue pathologies. CPP is becoming a serious …

Background: It has been recently recognized that the descending serotonin (5-HT) system
from the rostral ventromedial medulla (RVM) in the brainstem and the 5-HT3 receptor …

The treatment of neuropathic pain remains a clinical challenge. Analgesic drugs and
antidepressants are frequently ineffective, and opioids may induce side effects, including …

Stimulation of the secondary somatosensory cortex (S2) has attenuated pain in humans and
inflammatory nociception in animals. Here we studied S2 stimulation-induced …

Background: Despite the extensive number of studies performed in the last 50 years, aimed
at describing the role of serotonin and its receptors in pain modulation at the spinal cord …

The aim of the present study was to examine the role of the spinal serotonergic system in the
pain relieving effect of spinal cord stimulation (SCS) using a rat model of mononeuropathy …

Emerging evidence implicates serotonergic descending facilitatory pathways from the
brainstem to the spinal cord in the maintenance of pathologic pain. Upregulation of the …