Liver fibrosis is caused by chronic liver damage and results in the aberrant accumulation of
extracellular matrix during disease progression. Despite the identification of the HAT …

The histone acetyltransferase p300 plays a pivotal role in regulating gene expression and
cellular phenotype through epigenetic mechanisms. It significantly influences lipid …

Background and Aims To identify the regulatory role of protein phosphatase 2A (PP2A) in
the development of liver disease, we generated a mouse model with hepatocyte‐specific …

Simple Summary Chronic liver injury and inflammation leads to excessive deposition of
extracellular matrix, known as liver fibrosis, and the distortion of the hepatic parenchyma …

Effective therapy for liver fibrosis is lacking. Here, we examined whether LP340, the lead
candidate of a new-generation of hydrazide-based HDAC1, 2, 3 inhibitors (HDACi) …

The tumor suppressor p53 is the central hub of a molecular network, which controls cell
proliferation and death, and also plays an important role in the occurrence and development …

Liver fibrosis, a major cause of morbidity and mortality worldwide, leads to liver damage,
seriously threatening human health. In our previous study, we demonstrated that 14 kDa …

New experimental research has demonstrated that hyaluronan (HA), a component of the
extracellular matrix, is involved in the development of liver fibrosis, with hyaluronan synthase …

Recently, we showed that parathyroid hormone-like hormone (PTHLH), a cytokine-like
polyprotein, is critical for extracellular matrix (ECM) deposition through the activation of …

Background and Purpose Activation of hepatic stellate cells (HSCs) is a crucial step in the
pathogenesis of hepatic fibrosis. Histone deacetylase (HDAC) is an attractive target in liver …