Decoding the 'fifth'nucleotide: impact of RNA pseudouridylation on gene expression and human disease

A Jalan, PJ Jayasree, P Karemore, KP Narayan… - Molecular …, 2024 - Springer
Cellular RNAs, both coding and noncoding are adorned by> 100 chemical modifications,
which impact various facets of RNA metabolism and gene expression. Very often …

[HTML][HTML] RNA pseudouridylation in physiology and medicine: for better and for worse

M Penzo, AN Guerrieri, F Zacchini, D Treré… - Genes, 2017 - mdpi.com
Pseudouridine is the most abundant modification found in RNA. Today, thanks to next-
generation sequencing techniques used in the detection of RNA modifications …

Regulation and function of RNA pseudouridylation in human cells

EK Borchardt, NM Martinez… - Annual review of …, 2020 - annualreviews.org
Recent advances in pseudouridine detection reveal a complex pseudouridine landscape
that includes messenger RNA and diverse classes of noncoding RNA in human cells. The …

RNA pseudouridylation: new insights into an old modification

J Ge, YT Yu - Trends in biochemical sciences, 2013 - cell.com
Pseudouridine is the most abundant post-transcriptionally modified nucleotide in various
stable RNAs of all organisms. Pseudouridine is derived from uridine via base-specific …

Pseudouridine: the fifth RNA nucleotide with renewed interests

X Li, S Ma, C Yi - Current Opinion in Chemical Biology, 2016 - Elsevier
Highlights•Ψ is overall the most abundant RNA modification.•Ψ is wide-spread in ncRNAs
and plays important roles for their functions.•Ψ can be induced upon stress …

Recent developments, opportunities, and challenges in the study of mRNA pseudouridylation

WV Gilbert - RNA, 2024 - rnajournal.cshlp.org
Pseudouridine is an abundant mRNA modification found in diverse organisms ranging from
bacteria and viruses to multicellular plants and humans. New developments in …

Detection and quantification of pseudouridine in RNA

H Adachi, MD DeZoysa, YT Yu - Epitranscriptomics: Methods and …, 2019 - Springer
Pseudouridylation is the most abundant of all RNA modifications. Pseudouridylation is
dynamic and widespread among many different types of RNAs in living organisms, thus …

[PDF][PDF] Pseudouridine in RNA: what, where, how, and why

M Charette, MW Gray - IUBMB life, 2000 - bpg.utoledo.edu
Summary Pseudouridine (5-ribosyluracil) is a ubiquitous yet enigmatic constituent of
structural RNAs (transfer, ribosomal, small nuclear, and small nucleolar). Although …

[HTML][HTML] Pseudouridine in a new era of RNA modifications

BS Zhao, C He - Cell research, 2015 - nature.com
Pseudouridine (Ψ) was among the first post-transcriptional modifications discovered and is
overall one of the most abundant [1]. It is present in a wide range of cellular RNAs and is …

Pseudo-Seq: genome-wide detection of pseudouridine modifications in RNA

TM Carlile, MF Rojas-Duran, WV Gilbert - Methods in enzymology, 2015 - Elsevier
RNA molecules contain a variety of chemically diverse, posttranscriptionally modified bases.
The most abundant modified base found in cellular RNAs, pseudouridine (Ψ), has recently …