Epithelial cell dysfunction, a major driver of asthma development
IH Heijink, VNS Kuchibhotla, MP Roffel, T Maes… - Allergy, 2020 - Wiley Online Library
Airway epithelial barrier dysfunction is frequently observed in asthma and may have
important implications. The physical barrier function of the airway epithelium is tightly …
important implications. The physical barrier function of the airway epithelium is tightly …
Airway epithelial barrier function regulates the pathogenesis of allergic asthma
IH Heijink, MC Nawijn… - Clinical & Experimental …, 2014 - Wiley Online Library
The integrity of the airway epithelium in patients with asthma is often disrupted, with loss of
epithelial cell–cell contacts. Airway epithelial barrier dysfunction may have important …
epithelial cell–cell contacts. Airway epithelial barrier dysfunction may have important …
Epithelial function and dysfunction in asthma
Asthma was previously defined as an allergic Th2‐mediated inflammatory immune disorder.
Recently, this paradigm has been challenged because not all pathological changes …
Recently, this paradigm has been challenged because not all pathological changes …
The airway epithelium—A central player in asthma pathogenesis
J Calvén, E Ax, M Rådinger - International Journal of Molecular Sciences, 2020 - mdpi.com
Asthma is a chronic inflammatory airway disease characterized by variable airflow
obstruction in response to a wide range of exogenous stimuli. The airway epithelium is the …
obstruction in response to a wide range of exogenous stimuli. The airway epithelium is the …
The genetic and epigenetic landscapes of the epithelium in asthma
Asthma is a global health problem with increasing prevalence. The airway epithelium is the
initial barrier against inhaled noxious agents or aeroallergens. In asthma, the airway …
initial barrier against inhaled noxious agents or aeroallergens. In asthma, the airway …
Epigenetic regulation of airway epithelium immune functions in asthma
B Alashkar Alhamwe, S Miethe… - Frontiers in …, 2020 - frontiersin.org
Asthma is a chronic inflammatory disease of the respiratory tract characterized by recurrent
breathing problems resulting from airway obstruction and hyperresponsiveness. Human …
breathing problems resulting from airway obstruction and hyperresponsiveness. Human …
Epithelial barriers in allergy and asthma
PW Hellings, B Steelant - Journal of Allergy and Clinical Immunology, 2020 - Elsevier
The respiratory epithelium provides a physical, functional, and immunologic barrier to
protect the host from the potential harming effects of inhaled environmental particles and to …
protect the host from the potential harming effects of inhaled environmental particles and to …
The airway epithelium is central to the pathogenesis of asthma
ST Holgate - Allergology International, 2008 - jstage.jst.go.jp
Asthma is an inflammatory disorder principally involving the conducting airways and
characterised by infiltration of the airway wall with a range of inflammatory cells driven in …
characterised by infiltration of the airway wall with a range of inflammatory cells driven in …
Asthma: a disease of inflammation and repair
R Djukanović - Journal of allergy and clinical immunology, 2000 - Elsevier
Mucosal inflammation and more recently airway remodeling continue to be a focus of
interest when considering both the pathophysiology and treatment of asthma. Although a …
interest when considering both the pathophysiology and treatment of asthma. Although a …
The role of the airway epithelium and its interaction with environmental factors in asthma pathogenesis
Asthma is an inflammatory disorder of the airways dominated by a Th2-type pattern.
Because of this, most research has focused on investigating the role of allergic pathways …
Because of this, most research has focused on investigating the role of allergic pathways …