Multiple Intermediates in the Detergent-Induced Fusion of Lipid Vesicles

LG Dresser, C Kunstmann, D Conteduca, S Johnson… - bioRxiv, 2023 - biorxiv.org
The structure, dynamics and function of lipid vesicles are heavily influenced by a range of
physical forces, local microenvironmental effects and interactions with perturbative …

Controlled fusion of synthetic lipid membrane vesicles

M Ma, D Bong - Accounts of chemical research, 2013 - ACS Publications
Lipid membrane fusion is a fundamental noncovalent transformation as well as a central
process in biology. The complex and highly controlled biological machinery of fusion has …

Unveiling the multi-step solubilization mechanism of sub-micron size vesicles by detergents

PA Dalgarno, J Juan-Colás, GJ Hedley, L Piñeiro… - Scientific reports, 2019 - nature.com
The solubilization of membranes by detergents is critical for many technological applications
and has become widely used in biochemistry research to induce cell rupture, extract cell …

Membrane fusion of pH-sensitive liposomes–a quantitative study using giant unilamellar vesicles

S Trier, JR Henriksen, TL Andresen - Soft Matter, 2011 - pubs.rsc.org
Drug delivery systems based on liposome carriers that are designed for induction of
membrane fusion in response to the microenvironment have been investigated for more …

[HTML][HTML] Crowding-induced morphological changes in synthetic lipid vesicles determined using smFRET

SD Quinn, L Dresser, S Graham… - … in Bioengineering and …, 2022 - frontiersin.org
Lipid vesicles are valuable mesoscale molecular confinement vessels for studying
membrane mechanics and lipid-protein interactions, and they have found utility among bio …

Salt-induced lipid transfer between colloidal supported lipid bilayers

EL Kendall, E Mills, J Liu, X Jiang, CJ Brinker… - Soft Matter, 2010 - pubs.rsc.org
We show that a coordinated interplay between mesoscale colloidal interactions and
molecular-scale membrane perturbations affords a novel material platform to controllably …

Integrated suspended lipid membrane platform: Harnessing amperometric and single-molecule capabilities for deep insights into fusion dynamics

JS Weerakkody, S Thoduvayil, S Ramakrishnan - Biophysical Journal, 2024 - cell.com
Cellular plasma membranes are central to molecular transport and signaling. Traditional
models, reliant on lipid mixing and content release techniques, provide limited clarity on the …

Fusion modifies the material properties of membranes

RB Lira, C Richards, RRM Cavalcanti, C Aberg… - Biophysical …, 2023 - cell.com
Membrane fusion is a ubiquitous process in biology and potentially an alternative to
endocytic internalization pathways in drug delivery. Due to its high complexity, assays have …

Size-dependent, stochastic nature of lipid exchange between nano-vesicles and model membranes

SR Tabaei, JJJ Gillissen, S Vafaei, JT Groves, NJ Cho - Nanoscale, 2016 - pubs.rsc.org
The interaction of nanoscale lipid vesicles with cell membranes is of fundamental
importance for the design and development of vesicular drug delivery systems. Here, we …

Membrane-embedded nanoparticles induce lipid rearrangements similar to those exhibited by biological membrane proteins

RC Van Lehn, A Alexander-Katz - The Journal of Physical …, 2014 - ACS Publications
Amphiphilic monolayer-protected gold nanoparticles (NPs) have recently been shown to
spontaneously fuse with lipid bilayers under typical physiological conditions. The final …