Inflammatory bowel disease is a chronic autoimmune disorder that may involve entire
gastrointestinal tract. The leukotrienes have a role as mediators in the pathophysiology of …

The leukotrienes, lipid mediators, have a role in gastric damage induced by ethanol. Here,
the gastroprotective effect of montelukast, an antagonist of the leukotriene receptor, and the …

Cysteinyl leukotrienes play a part in inflammatory processes such as inflammatory bowel
diseases. The present study aimed to evaluate the effects of the cys-LT-1 receptor …

Aim The purpose of the present study is to explore the anti-inflammatory potential of
risperidone in acetic acid-induced rat colitis through inhibition of TLR4/NF-kB pathway …

Irritable bowel syndrome (IBS) is a functional gut disorder with multi-factorial
pathophysiology that causes recurring pain or discomfort in the abdomen, as well as altered …

Anti-allergic drugs such as sodium cromoglycate are known to be effective for the treatment
of ulcerative colitis (UC). Because leukotriene (LT) production is considered to play an …

Leukotrienes play a part in inflammatory response. The unique role of the enzyme 5-
lipoxygenase (5-LOX) in the production of leukotrienes makes it a likely therapeutic target for …

We investigated the potential protective effects of montelukast (MLK) on cecal ligation and
puncture (CLP)–induced tissue injury in vital organs—liver, heart, kidneys, and especially …

Ulcerative colitis (UC) is a chronic disease driven primarily by uncontrolled pervasive
inflammatory responses affecting the colon and rectum. Currently available medications …

Background: Juglone is a phenolic bioactive compound with antimicrobial, antitumour,
antioxidant, and anti-inflammatory characteristics. Given its anti-inflammatory and …