One-month assessment of Th-cell axis related inflammatory cytokines, IL-17 and IL-22 and their role in alcohol-associated liver disease
M Sagaram, J Frimodig, D Jayanty, H Hu… - Frontiers in …, 2023 - frontiersin.org
Introduction Changes in the expression of cyto-and chemokines due to alcohol-associated
liver disease (ALD) have been reported to be both protective and pathogenic. This study …
liver disease (ALD) have been reported to be both protective and pathogenic. This study …
Highest frequencies of interleukin-22-producing T helper cells in alcoholic hepatitis patients with a favourable short-term course
S Støy, TD Sandahl, AK Dige, J Agnholt… - PloS one, 2013 - journals.plos.org
Background Alcoholic hepatitis (AH) has a severe prognosis due to hepatic inflammatory
injury. The cytokine interleukin-22 (IL-22) is reported to exert anti-apoptotic and proliferative …
injury. The cytokine interleukin-22 (IL-22) is reported to exert anti-apoptotic and proliferative …
Serum Concentrations of Th17-Associated Interleukins and Autoimmune Phenomena are Associated with the Degree of Liver Damage in Alcoholic Liver Disease.
A Parfieniuk-Kowerda, M Swiderska… - … of Gastrointestinal & …, 2017 - search.ebscohost.com
Abstract Background & Aims: Recent reports suggest an involvement of Th17
responses in inflammatory and autoimmune reactions in alcoholic liver disease (ALD). Our …
responses in inflammatory and autoimmune reactions in alcoholic liver disease (ALD). Our …
Interleukin-11 drives human and mouse alcohol-related liver disease
M Effenberger, AA Widjaja, F Grabherr, B Schaefer… - Gut, 2023 - gut.bmj.com
Objective Alcoholic hepatitis (AH) reflects acute exacerbation of alcoholic liver disease
(ALD) and is a growing healthcare burden worldwide. Interleukin-11 (IL-11) is a profibrotic …
(ALD) and is a growing healthcare burden worldwide. Interleukin-11 (IL-11) is a profibrotic …
Prognostic significance of the systemic inflammatory and immune balance in alcoholic liver disease with a focus on gender-related differences
B Kasztelan-Szczerbińska, A Surdacka, K Celiński… - PloS one, 2015 - journals.plos.org
Objectives Mechanisms of immune regulation in alcoholic liver disease (ALD) are still
unclear. The aim of our study was to determine an impact of Th17/regulatory T (Treg) cells …
unclear. The aim of our study was to determine an impact of Th17/regulatory T (Treg) cells …
[HTML][HTML] Low interleukin-22 binding protein is associated with high mortality in alcoholic hepatitis and modulates interleukin-22 receptor expression
S Støy, TL Laursen, E Glavind, PL Eriksen… - Clinical and …, 2020 - journals.lww.com
METHODS: We prospectively studied 41 consecutive patients with AH at diagnosis, days 7
and 90, and followed them for up to 1 year. We measured IL-22 pathway proteins in liver …
and 90, and followed them for up to 1 year. We measured IL-22 pathway proteins in liver …
The interleukin‐17 pathway is involved in human alcoholic liver disease
Immune dysregulations in alcoholic liver diseases are still unclear, especially regarding
alcoholic hepatitis inflammatory burst. Interleukin‐17 (IL‐17) is known to enhance neutrophil …
alcoholic hepatitis inflammatory burst. Interleukin‐17 (IL‐17) is known to enhance neutrophil …
Interleukin-22 in alcoholic hepatitis and beyond
Alcoholic hepatitis (AH) is a clinical syndrome characterized by jaundice and progressive
inflammatory liver injury in patients with a history of prolonged periods of excess alcohol …
inflammatory liver injury in patients with a history of prolonged periods of excess alcohol …
Lipopolysaccharide downregulates macrophage-derived IL-22 to modulate alcohol-induced hepatocyte cell death
Y Liu, VK Verma, H Malhi, GJ Gores… - … of Physiology-Cell …, 2017 - journals.physiology.org
Interleukin-22 (IL-22) is a Th17 cell hepatoprotective cytokine that is undergoing clinical
trials to treat patients with alcoholic hepatitis (AH). Lipopolysaccharide (LPS) activation of …
trials to treat patients with alcoholic hepatitis (AH). Lipopolysaccharide (LPS) activation of …
Ethanol‐mediated suppression of IL‐37 licenses alcoholic liver disease
F Grabherr, C Grander, TE Adolph, V Wieser… - Liver …, 2018 - Wiley Online Library
Abstract Background & Aims Chronic alcohol consumption and alcoholic liver disease (ALD)
afflicts individuals with substantial morbidity and mortality with limited treatment options …
afflicts individuals with substantial morbidity and mortality with limited treatment options …