The Ser/Thr kinase Akt (Protein Kinase B/PKB) is a master switch in cellular signal
transduction pathways. Its downstream signaling influences cell proliferation, cell growth …

Targeting and stabilizing distinct kinase conformations is an instrumental strategy for
dissecting conformation‐dependent signaling of protein kinases. Herein the structure‐based …

Protein kinase B/AKT plays a central role in cancer. The serine/threonine kinase is over-
expressed or constitutively active in many cancers and has been validated as a therapeutic …

AKT1 (NP_005154. 2) is a member of the serine/threonine AGC protein kinase family
involved in cellular metabolism, growth, proliferation and survival. The three human AKT …

This article describes recent advances in the development and biological evaluation of small
molecule inhibitors for the serine/threonine kinase Akt (PKB). Akt plays a pivotal role in cell …

Isoforms of protein kinase Akt are involved in essential processes including cell proliferation,
survival, and metabolism. However, their individual roles in health and disease have not …

This article describes recent advances in the development and biological evaluation of small
molecule inhibitors for the serine/threonine kinase Akt (PKB) as a reprise of our 2005 review …

This article describes recent advances in the development and biological evaluation of small
molecule inhibitors for the serine/threonine kinase Akt (PKB). Akt plays a pivotal role in cell …

The phosphatidylinositol 3-kinase/AKT signaling pathway plays a critical role in activating
survival and antiapoptotic pathways within cancer cells. Several studies have shown that …

Disruption of the phosphatidylinositol 3-kinase/AKT signaling pathway can lead to apoptosis
in cancer cells. Previously we identified a lead sulfonamide that selectively bound to the …