Starting 90 years ago with a clinical description by Glanzmann of a bleeding disorder
associated with a defect in platelet function, technologic advances helped investigators …

Platelet membrane glycoprotein (GP) IIb/IIIa (αIIbβ3), a Ca2+-dependent heterodimer,
serves as an inducible receptor for fibrinogen and other adhesive plasma proteins, and is …

This article reports a Glanzmann thrombasthenia (GT) patient, NM, with a point mutation in
the third cysteine-rich repeat of β3-integrin or platelet glycoprotein (GP) IIIa, leading to the …

Haemostasis is a finely balanced and complex process ideally initiated only in response to
disruption of the vascular endothelium as a means of preventing loss of blood from an …

The glycoprotein (GP) IIb/IIIa, a Ca 2+-dependent heterodimer, is the major integrin on the
platelet plasma membrane. On resting platelets GPIIb/IIIa is maintained in an inactive …

From the discovery of the platelet glycoprotein (GP) IIb/IIIa and identification of its central role
in haemostasis, the integrin GPIIb/IIIa (αIIbβ3, CD41/CD61) was destined to be an anti …

αIIbβ3, the major membrane protein on the surface of platelets, is a member of the integrin
family of heterodimeric adhesion receptors. The αIIb and β3 subunits are each composed of …

Integrin αIIbβ3 plays a critical role in platelet aggregation through its interaction with
fibrinogen. Elucidation of the mechanisms of αIIbβ3-fibrinogen interaction is critical to …

Integrin α IIb β 3 plays a critical role in platelet aggregation, a central response in
hemostasis and thrombosis. This function of α IIb β 3 depends upon a transition from a …

The major platelet integrin, αIIbβ3, is required for platelet interactions with proteins in plasma
and the extracellular matrices (ECMs) that are essential for platelet adhesion and …