[HTML][HTML] TIM3 comes of age as an inhibitory receptor
T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM
family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and …
family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and …
Tim-3, a negative regulator of anti-tumor immunity
AC Anderson - Current opinion in immunology, 2012 - Elsevier
T cell immunoglobulin-3 (Tim-3) was identified nearly 10 years ago as a negative regulator
of IFN-γ-secreting CD4+ T helper 1 and CD8+ T cytotoxic 1 cells. Tim-3 is now classed with …
of IFN-γ-secreting CD4+ T helper 1 and CD8+ T cytotoxic 1 cells. Tim-3 is now classed with …
[HTML][HTML] Immune regulation by Tim-3
H Banerjee, LP Kane - F1000Research, 2018 - ncbi.nlm.nih.gov
T-cell immunoglobulin and mucin domain 3 (Tim-3) is a transmembrane protein that in both
mice and humans has been shown to possess various functions in a context-dependent …
mice and humans has been shown to possess various functions in a context-dependent …
Significance of TIM3 expression in cancer: From biology to the clinic
C Solinas, P De Silva, D Bron, K Willard-Gallo… - Seminars in …, 2019 - Elsevier
Targeting inhibitory immune checkpoint molecules has dramatically changed treatment
paradigms in medical oncology. Understanding the best strategies to unleash a pre-existing …
paradigms in medical oncology. Understanding the best strategies to unleash a pre-existing …
Tim‐3 and its role in regulating anti‐tumor immunity
M Das, C Zhu, VK Kuchroo - Immunological reviews, 2017 - Wiley Online Library
Immunotherapy is being increasingly recognized as a key therapeutic modality to treat
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …
cancer and represents one of the most exciting treatments for the disease. Fighting cancer …
Tim-3: A co-receptor with diverse roles in T cell exhaustion and tolerance
R Tang, M Rangachari, VK Kuchroo - Seminars in immunology, 2019 - Elsevier
T cell inhibitory co-receptors play a crucial role in maintaining the balance between
physiologic immune responses and maladaptive ones. T cell immunoglobulin and mucin …
physiologic immune responses and maladaptive ones. T cell immunoglobulin and mucin …
[HTML][HTML] TIM-3 as a Target for Cancer Immunotherapy and Mechanisms of Action
Cancer immunotherapy has produced impressive clinical results in recent years. Despite the
success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 …
success of the checkpoint blockade strategies targeting cytotoxic T lymphocyte antigen 4 …
TIM-3 restrains anti-tumour immunity by regulating inflammasome activation
T cell immunoglobulin and mucin-containing molecule 3 (TIM-3), first identified as a
molecule expressed on interferon-γ producing T cells, is emerging as an important immune …
molecule expressed on interferon-γ producing T cells, is emerging as an important immune …
TIM-3 pathway dysregulation and targeting in cancer
AM Zeidan, RS Komrokji… - Expert Review of …, 2021 - Taylor & Francis
Introduction Dysfunction of the immune system is a hallmark of cancer. Through increased
understanding of the complex interactions between immunity and cancer, immunotherapy …
understanding of the complex interactions between immunity and cancer, immunotherapy …
Tim-3: an emerging target in the cancer immunotherapy landscape
AC Anderson - Cancer immunology research, 2014 - AACR
The cancer immunotherapy field has grown exponentially in the past few years, largely
driven by the success of immune checkpoint blockade. Therapies targeting the immune …
driven by the success of immune checkpoint blockade. Therapies targeting the immune …