Potential anti-COVID-19 therapeutics that block the early stage of the viral life cycle: structures, mechanisms, and clinical trials

RA Al-Horani, S Kar, KF Aliter - International Journal of Molecular …, 2020 - mdpi.com
The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe
acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present …

Potential anti-SARS-CoV-2 therapeutics that target the post-entry stages of the viral life cycle: A comprehensive review

RA Al-Horani, S Kar - Viruses, 2020 - mdpi.com
The coronavirus disease-2019 (COVID-19) pandemic continues to challenge health care
systems around the world. Scientists and pharmaceutical companies have promptly …

Mechanism of action of small-molecule agents in ongoing clinical trials for SARS-CoV-2: a review

L Zhao, S Li, W Zhong - Frontiers in Pharmacology, 2022 - frontiersin.org
Since the first reports from December 2019, COVID-19 caused an overwhelming global
pandemic that has affected 223 countries, seriously endangering public health and creating …

The chronicle of COVID-19 and possible strategies to curb the pandemic

R Kumar, S Harilal, AG Al-Sehemi… - Current Medicinal …, 2021 - ingentaconnect.com
COVID-19, a type of infection that emerged in Wuhan, has become a pandemic affecting
people worldwide and is rapidly spreading and evolving. Day by day, the confirmed cases …

Therapeutic targets and interventional strategies in COVID-19: mechanisms and clinical studies

YW Zhou, Y Xie, LS Tang, D Pu, YJ Zhu… - Signal transduction and …, 2021 - nature.com
Owing to the limitations of the present efforts on drug discovery against severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) and the lack of the understanding of the …

Drugs targeting various stages of the SARS-CoV-2 life cycle: Exploring promising drugs for the treatment of Covid-19

R Poduri, G Joshi, G Jagadeesh - Cellular signalling, 2020 - Elsevier
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense,
single-stranded RNA virus that causes the potentially lethal Covid-19 respiratory tract …

The race to treat COVID-19: Potential therapeutic agents for the prevention and treatment of SARS-CoV-2

I Ahmad - European journal of medicinal chemistry, 2021 - Elsevier
The unforeseen emergence of coronavirus disease 2019 (COVID-19), a severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) at the Wuhan province of China in …

An overview on anti-COVID-19 drug achievements and challenges ahead

M Valipour, H Irannejad, H Keyvani - ACS Pharmacology & …, 2023 - ACS Publications
The appearance of several coronavirus pandemics/epidemics during the last two decades
(SARS-CoV-1 in 2002, MERS-CoV in 2012, and SARS-CoV-2 in 2019) indicates that …

Potential therapeutic targets and promising drugs for combating SARS‐CoV‐2

H Zhou, Y Fang, T Xu, WJ Ni, AZ Shen… - British Journal of …, 2020 - Wiley Online Library
As of April 9, 2020, a novel coronavirus (SARS‐CoV‐2) had caused 89,931 deaths and
1,503,900 confirmed cases worldwide, which indicates an increasingly severe and …

After the hurricane: Anti-COVID-19 drugs development, molecular mechanisms of action and future perspectives

HO Khalifa, YM Al Ramahi - International Journal of Molecular Sciences, 2024 - mdpi.com
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is a new coronavirus in
the Coronaviridae family. The COVID-19 pandemic, caused by SARS-CoV-2, has …