Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals

P Xu, K Qiao, WS Ahn… - Proceedings of the …, 2016 - National Acad Sciences
Harnessing lipogenic pathways and rewiring acyl-CoA and acyl-ACP (acyl carrier protein)
metabolism in Yarrowia lipolytica hold great potential for cost-efficient production of diesel …

Synthetic biology, systems biology, and metabolic engineering of Yarrowia lipolytica toward a sustainable biorefinery platform

J Ma, Y Gu, M Marsafari, P Xu - … : Official Journal of the Society for …, 2020 - academic.oup.com
Yarrowia lipolytica is an oleaginous yeast that has been substantially engineered for
production of oleochemicals and drop-in transportation fuels. The unique acetyl …

Metabolic engineering in the host Yarrowia lipolytica

AM Abdel-Mawgoud, KA Markham, CM Palmer… - Metabolic …, 2018 - Elsevier
The nonconventional, oleaginous yeast, Yarrowia lipolytica is rapidly emerging as a
valuable host for the production of a variety of both lipid and nonlipid chemical products …

Engineering the Lipid and Fatty Acid Metabolism in Yarrowia lipolytica for Sustainable Production of High Oleic Oils

K Wang, TQ Shi, J Wang, P Wei… - ACS Synthetic …, 2022 - ACS Publications
Oleic acid is widely applied in the chemical, material, nutritional, and pharmaceutical
industries. However, the current production of oleic acid via high oleic plant oils is limited by …

Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production

J Blazeck, A Hill, L Liu, R Knight, J Miller, A Pan… - Nature …, 2014 - nature.com
Economic feasibility of biosynthetic fuel and chemical production hinges upon harnessing
metabolism to achieve high titre and yield. Here we report a thorough genotypic and …

Engineering Yarrowia lipolytica to Produce Tailored Chain-Length Fatty Acids and Their Derivatives

K Wang, TQ Shi, L Lin, P Wei… - ACS synthetic …, 2022 - ACS Publications
Microbial production of value-added chemicals derived from fatty acids is a sustainable
alternative to petroleum-derived chemicals and unsustainable lipids from animals and …

Overproduction of Fatty Acid Ethyl Esters by the Oleaginous Yeast Yarrowia lipolytica through Metabolic Engineering and Process Optimization

Q Gao, X Cao, YY Huang, JL Yang, J Chen… - ACS synthetic …, 2018 - ACS Publications
Recent advances in the production of biofuels by microbes have attracted attention due to
increasingly limited fossil fuels. Biodiesels, especially fatty acid ethyl esters (FAEEs), are …

Production of Medium Chain Fatty Acids by Yarrowia lipolytica: Combining Molecular Design and TALEN to Engineer the Fatty Acid Synthase

C Rigouin, M Gueroult, C Croux, G Dubois… - ACS synthetic …, 2017 - ACS Publications
Yarrowia lipolytica is a promising organism for the production of lipids of biotechnological
interest and particularly for biofuel. In this study, we engineered the key enzyme involved in …

Holistic approaches in lipid production by Yarrowia lipolytica

Z Lazar, N Liu, G Stephanopoulos - Trends in biotechnology, 2018 - cell.com
Concerns about climate change have driven research on the production of lipid-derived
biofuels as an alternative and renewable liquid fuel source. Using oleaginous yeasts for lipid …

Alternative Substrate Metabolism in Yarrowia lipolytica

M Spagnuolo, M Shabbir Hussain, L Gambill… - Frontiers in …, 2018 - frontiersin.org
Recent advances in genetic engineering capabilities have enabled the development of
oleochemical producing strains of Yarrowia lipolytica. Much of the metabolic engineering …