Cyclin-dependent kinases (CDKs) are protein kinases characterized by needing a separate
subunit-a cyclin-that provides domains essential for enzymatic activity. CDKs play important …

Cyclin-dependent kinases (CDKs) are serine/threonine protein kinases with a well
established role in the regulation of the eukaryotic cell cycle. Recent studies with animal …

Cyclin-dependent kinases (CDKs) are protein kinases involved in critical cellular processes,
such as cell cycle or transcription, whose activity requires association with specific cyclin …

Cyclin-dependent kinases (CDKs) have been recognized as key regulators of cell cycle
progression. Alteration and deregulation of CDK activity are pathogenic hallmarks of …

Background Protein phosphorylation regulates a multitude of biological processes.
However, the large number of protein kinases and their substrates generates an enormously …

Cyclin-dependent kinases (CDKs) function as central regulators of both the cell cycle and
transcription. CDK activation depends on phosphorylation by a CDK-activating kinase …

Abstract Background Cyclin-dependent kinases (CDKs) are a large family of proteins that
function in a variety of key regulatory pathways in eukaryotic cells, including control over the …

In metazoans, different cyclin-dependent kinases (CDKs) bind preferred cyclin partners to
coordinate cell division. Here, we investigate these preferences in human cells and show …

Cyclin-dependent kinases regulate the cell cycle and transcription in higher eukaryotes. We
have determined the crystal structure of the transcription kinase Cdk13 and its Cyclin K …

The quantitative model of cyclin-dependent kinase (CDK) function states that cyclins
temporally order cell cycle events at different CDK activity levels, or thresholds. The model …