Kraepelin, in his early descriptions of schizophrenia (SZ), characterized the illness as having
“an orchestra without a conductor.” Kraepelin further speculated that this “conductor” was …

The core features of schizophrenia include deficits in cognitive processes mediated by the
circuitry of the dorsolateral prefrontal cortex (DLPFC). These deficits are associated with a …

Evidence is reviewed that one of the cognitive-affective parallel circuits in the brain, the
dorsolateral prefrontal circuit, is compromised at the level of anatomical, neuropathological …

Objective: Although deficits in cognitive control are thought to contribute to the diverse
cognitive and behavioral abnormalities in individuals with schizophrenia, the neural …

Clinical and experimental research have provided anatomical, pharmacological, and
behavioral evidence for a prominent prefrontal dysfunction in schizophrenia. Negative …

Background Two brain regions often implicated in schizophrenia are the dorsolateral
prefrontal cortex (DLPFC) and the hippocampal formation (HF). It has been hypothesized …

Schizophrenia is associated with alterations in working memory that reflect dysfunction of
dorsolateral prefrontal cortex (DLPFC) circuitry. Working memory depends on the activity of …

Cognitive deficits are central to schizophrenia, but the underlying mechanisms still remain
unclear. Imaging studies performed in patients point to decreased activity in the mediodorsal …

BACKGROUND: The theory that prefrontal cortex (PFC) dysfunction in schizophrenia leads
to excess subcortical dopamine has generated widespread interest because it provides a …

Impaired cognitive functioning, including deficits in working memory, is considered to be a
core and disabling feature of schizophrenia that is difficult to treat. Deficits in working …