CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …

The importance of CD4 T cells in orchestrating the immune system and their role in inducing
effective T cell-mediated therapies for the treatment of patients with select established …

The role of CD8 T cells in adaptive immune responses is well understood. These
lymphocytes respond through their T cell receptors to diverse antigens presented by MHC …

Inflammation contributes to the development and perpetuation of several disorders and T
lymphocytes orchestrate the inflammatory immune response. Although the role of T cells in …

Research over the past decade has revealed the increasingly complex biologic features of
the CD4+ T-cell lineage. This T-cell subset, which was originally defined on the basis of …

Human beings are exposed to a variety of different pathogens, which induce tailored
immune responses and consequently generate highly diverse populations of pathogen …

The crucial role of CD4+ and CD8+ T cells in shaping and controlling immune responses
during immune disease and cancer development has been well established and used to …

In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T
cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three …

CD4 effector T cells, also called helper T (Th) cells, are the functional cells for executing
immune functions. Balanced immune responses can only be achieved by proper regulation …

CD4+ T-cell-mediated immune responses are instrumental to eliminate viral, bacterial,
fungal, or parasitic infections or malignant cells through secretion of cytokines and activation …