Liver X receptors (LXRs) are ligand-dependent transcription factors that are activated by
metabolites of cholesterol, oxysterols, and a number of synthetic agonists. LXRs play potent …

The liver X receptors (LXRs) are nuclear receptors that play central roles in the
transcriptional control of lipid metabolism. LXRs function as nuclear cholesterol sensors that …

Recent studies have identified the liver X receptors (LXRα and LXRβ) as important
regulators of cholesterol metabolism and transport. LXRs control transcription of genes …

First discovered as orphan receptors, liver X receptors (LXRs) were subsequently identified
as the nuclear receptor target of the cholesterol metabolites, oxysterols. There are 2 LXR …

Liver X receptors (LXRs) are nuclear receptors that play a central role in cholesterol
metabolism. When activated, LXRs induce a series of genes that are involved in cholesterol …

Atherosclerosis is a disease characterized by excess cholesterol and inflammation in the
blood vessels. The liver X receptors (alpha and beta) are members of the nuclear hormone …

Liver X receptors (LXR) are oxysterol-activated nuclear receptors that play a central role in
reverse cholesterol transport through up-regulation of ATP-binding cassette transporters …

Objective—Complications of atherosclerotic cardiovascular disease due to elevated blood
cholesterol levels are the major cause of death in the Western world. The liver X receptors …

Background—Liver X receptors (LXRs) are ligand-activated transcription factors involved in
the control of lipid metabolism and inflammation. Synthetic LXR agonists have been shown …

Cholesterol homeostasis is maintained through the coordinated regulation of the trafficking,
biosynthesis, absorption, and efflux of cholesterol. From the discovery that atherosclerotic …