[HTML][HTML] Antimicrobial, Immunomodulatory and Anti-Inflammatory Potential of Liposomal Thymoquinone: Implications in the Treatment of Bacterial Pneumonia in …

KS Allemailem, A Almatroudi, F Alrumaihi… - Biomedicines, 2021 - mdpi.com
Acinetobacter baumannii has recently been increasing as an aggressive pathogen in
immunocompromised persons. In the present study, we determined the in vitro antibacterial …

Thymoquinone Ameliorates Lung Inflammation and Pathological Changes Observed in Lipopolysaccharide‐Induced Lung Injury

M Boskabady, MR Khazdair, R Bargi… - Evidence‐Based …, 2021 - Wiley Online Library
Anti‐inflammatory, antioxidant, and immunomodulatory effects of thymoquinone (TQ) have
been shown. The effects of TQ on lipopolysaccharide‐(LPS‐) induced inflammation and …

Ameliorative Effect of Thymoquinone‐Loaded PLGA Nanoparticles on Chronic Lung Injury Induced by Repetitive Intratracheal Instillation of Lipopolysaccharide in …

SAM Saghir, NA Al-Gabri, AA Ali… - Oxidative Medicine …, 2021 - Wiley Online Library
Thymoquinone (TQ), the active constituent of Nigella sativa, possesses several benefits in
traditional and modern medicines. This study examined the effect of a single dose of Nano …

Thymoquinone ameliorates pulmonary vascular damage induced byEscherichia coli–derived lipopolysaccharide via cytokine downregulation in rats

NA Al-Gabri, MM Qaid, NH El-Shaer, MH Ali… - … Science and Pollution …, 2019 - Springer
Our study investigated the ameliorative effects of thymoquinone (TQ) on the pulmonary
blood vessels which were injured after intratracheal administration of Escherichia coli …

[HTML][HTML] Safety and Therapeutic Efficacy of Thymoquinone-Loaded Liposomes against Drug-Sensitive and Drug-Resistant Acinetobacter baumannii

KS Allemailem, AM Alnuqaydan, A Almatroudi… - Pharmaceutics, 2021 - mdpi.com
In the present study, we investigated the activity of free thymoquinone (TQ) or liposomal
thymoquinone (Lip-TQ) in comparison to standard antibiotic amoxicillin (AMX) against the …

Pathological study on the role of thymoquinone in experimentally induced acute lung injury in rats

NA Al-Gabri, AM Ali, ES AL-Attar… - Zagazig Veterinary …, 2017 - zvjz.journals.ekb.eg
Acute lung injury (ALI) is a major cause of morbidity and mortality in humans and animals. In
traditional and modern medicines, Nigella sativa extract, thymoquinone (TQ) has several …

[HTML][HTML] Thymoquinone reduces mortality and suppresses early acute inflammatory markers of sepsis in a mouse model

KM Alkharfy, A Ahmad, BL Jan, M Raish - Biomedicine & Pharmacotherapy, 2018 - Elsevier
Background Sepsis is a severe systemic condition caused by an excessive inflammatory
response to microbial infections, which often results in high mortality. Aims In the present …

[HTML][HTML] N-Chlorotaurine Reduces the Lung and Systemic Inflammation in LPS-Induced Pneumonia in High Fat Diet-Induced Obese Mice

N Khanh Hoang, E Maegawa, S Murakami… - Metabolites, 2022 - mdpi.com
Lung infection can evoke pulmonary and systemic inflammation, which is associated with
systemic severe symptoms, such as skeletal muscle wasting. While N-chlorotaurine (also …

Preventive and therapeutic effects of thymol in a lipopolysaccharide-induced acute lung injury mice model

L Wan, D Meng, H Wang, S Wan, S Jiang, S Huang… - Inflammation, 2018 - Springer
Acute lung injury (ALI) is a life-threatening syndrome which causes a high mortality rate
worldwide. In traditional medicine, lots of aromatic plants—such as some Thymus species …

[HTML][HTML] Thymoquinone (TQ) inhibits the replication of intracellular Mycobacterium tuberculosis in macrophages and modulates nitric oxide production

HA Mahmud, H Seo, S Kim, MI Islam, KW Nam… - … and alternative medicine, 2017 - Springer
Background Human tuberculosis, which is caused by the pathogen Mycobacterium
tuberculosis, remains a major public health concern. Increasing drug resistance poses a …