Aim The present study was carried out to evaluate the effect of 1.2% simvastatin gel as local
drug delivery (LDD) system on Gingival Crevicular Fluid (GCF) Interleukin-6 (IL-6) and …

Objectives The impact of simvastatin (SMV), a cholesterol lowering drug, on bone
metabolism appears to involve complex interaction with cholesterol metabolites, hormones …

Simvastatin (SMV) are specific competitive inhibitors which are widely used to lower
cholesterol for the treatment of hyperlipidemia and arteriosclerosis. They have shown to …

Background: The current understanding of the pathogenesis of periodontal disease has
resulted in adjunctive use of various pharmacologic agents in periodontal therapy. The …

Background: Periodontitis is an inflammatory disease that results in bone resorption creating
bony defects, which may cause tooth loss. Various drugs have been studied using local …

Objectives. This study aimed to analyse the levels of the proinflammatory cytokine IL-1β and
the anti-inflammatory cytokine IL-10 in gingival crevicular fluid (GCF) of patients with chronic …

Konopka Ł, Pietrzak A, Brzezińska‐Błaszczyk E. Effect of scaling and root planing on
interleukin‐1β, interleukin‐8 and MMP‐8 levels in gingival crevicular fluid from chronic …

Background Gene regulation of IL-6 is characterized by the presence of inflammatory
cytokines, bacterial products, viral infection, and activation of the diacylglycerol-, cyclic AMP …

Background: Simvastatin (SMV), a new locally delivered drug of class statins, is a specific
competitive inhibitor of 3-hydroxy-2-methyl-glutaryl coenzyme A reductase. Statins, besides …

Aim: The aim of this study was to evaluate the effect of nonsurgical periodontal therapy on
serum levels of interleukin-1β (IL-1β) and interleukin-8 (IL-8) in smokers and nonsmokers …