[HTML][HTML] Psilocybin restrains activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms

K Conn, LK Milton, K Huang, H Munguba… - Molecular …, 2024 - nature.com
Psilocybin has shown promise for alleviating symptoms of depression and is currently in
clinical trials for the treatment of anorexia nervosa (AN), a condition that is characterised by …

Psilocybin prevents activity-based anorexia in female rats by enhancing cognitive flexibility: contributions from 5-HT1A and 5-HT2A receptor mechanisms

K Conn, LK Milton, K Huang, H Munguba, J Ruuska… - bioRxiv, 2023 - biorxiv.org
Psilocybin has shown promise for alleviating symptoms of depression and is currently in
clinical trials for the treatment of anorexia nervosa (AN), a condition that is characterised by …

[HTML][HTML] Acute psilocybin enhances cognitive flexibility in rats

A Torrado Pacheco, RJ Olson, G Garza… - …, 2023 - nature.com
Psilocybin has been shown to improve symptoms of depression and anxiety when combined
with psychotherapy or other clinician-guided interventions. To understand the neural basis …

Psilocybin increases optimistic engagement over time: computational modelling of behavior in rats

EL Fisher, R Smith, K Conn, AW Corcoran, LK Milton… - bioRxiv, 2024 - biorxiv.org
Psilocybin has shown promise as a novel pharmacological intervention for treatment of
depression, where post-acute effects of psilocybin treatment have been associated with …

[HTML][HTML] Acute and long-term effects of psilocybin on energy balance and feeding behavior in mice

N Fadahunsi, J Lund, AW Breum, CV Mathiesen… - Translational …, 2022 - nature.com
Psilocybin and other serotonergic psychedelics have re-emerged as therapeutics for
neuropsychiatric disorders, including addiction. Psilocybin induces long-lasting effects on …

[HTML][HTML] Rethinking therapeutic strategies for anorexia nervosa: insights from psychedelic medicine and animal models

CJ Foldi, P Liknaitzky, M Williams… - Frontiers in …, 2020 - frontiersin.org
Anorexia nervosa (AN) has the highest mortality rate of any psychiatric disease, yet
available pharmacological treatments are largely ineffective due, in part, to an inadequate …

A single administration of psilocybin persistently rescues cognitive deficits caused by adolescent chronic restraint stress without long-term changes in synaptic protein …

M Hibicke, HM Kramer, CD Nichols - Psychedelic Medicine, 2023 - liebertpub.com
Introduction: Psilocybin has shown long-lasting antidepressant effects in preclinical and
clinical trials, but the mechanisms responsible are unclear. As both passive coping …

[HTML][HTML] Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles

SA Rogers, EA Heller, G Corder - bioRxiv, 2024 - ncbi.nlm.nih.gov
Abstract The serotonin 2 receptor (5HT2R) agonist psilocybin displays rapid and persistent
therapeutic efficacy across neuropsychiatric disorders characterized by cognitive inflexibility …

Repeated low doses of psilocybin increase resilience to stress, lower compulsive actions, and strengthen cortical connections to the paraventricular thalamic nucleus …

KF Kiilerich, J Lorenz, MB Scharff, N Speth… - Molecular …, 2023 - nature.com
Psilocybin (a classic serotonergic psychedelic drug) has received appraisal for use in
psychedelic-assisted therapy of several psychiatric disorders. A less explored topic …

[HTML][HTML] Psilocybin therapy increases cognitive and neural flexibility in patients with major depressive disorder

MK Doss, M Považan, MD Rosenberg… - Translational …, 2021 - nature.com
Psilocybin has shown promise for the treatment of mood disorders, which are often
accompanied by cognitive dysfunction including cognitive rigidity. Recent studies have …