IL-1β-secreting nucleotide-binding oligomerization domain protein 3 (NLRP3)
inflammasomes play a pivotal role in triggering innate immune responses in metabolic …

Hyperuricemic nephropathy (HN) is a common clinical complication of hyperuricemia. High-
serum uric acid can trigger renal inflammation. The inflammasome family has several …

Hyperuricemia is an independent risk factor for the progression of chronic kidney disease.
High levels of uric acid can lead to a series of pathological conditions, such as gout, urinary …

While inflammation is considered a central component in the development in diabetic
nephropathy, the mechanism remains unclear. The NLRP3 inflammasome acts as both a …

Background Nucleotide leukin-rich polypeptide 3 (NLRP3) inflammasome is documented as
a potent target for treating metabolic diseases and inflammatory disorders. Our recent work …

Diabetic nephropathy (DN) is a serious complication of diabetes mellitus, and persistent
inflammation in circulatory and renal tissues is an important pathophysiological basis for DN …

Diabetic nephropathy is a growing health concern with characteristic sterile inflammation. As
the underlying mechanisms of this inflammation remain poorly defined, specific therapies …

Efficient therapies for diabetic kidney disease (DKD), now the leading cause of kidney
failure, are lacking. One hallmark of DKD is sterile inflammation (inflammation in absence of …

The NOD-like receptor protein 3 (NLRP3) inflammasome is a multi-protein signalling
complex integral to the chronic inflammatory response, activated in response to sterile and …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Activation of the
nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing …