Impaired immune function has been implicated in the declining health and higher incidence
of cancer in the elderly. However, age-related changes to immunity are not completely …

Over the past millennia, life expectancy has drastically increased. While a mere 25 years
during Bronze and Iron ages, life expectancy in many European countries and in Japan is …

Human neutrophils are activated by a wide array of compounds through their receptors. This
elicits their classical functions, such as chemotaxis, phagocytosis, and the production of …

A fully functioning immune system is essential in order to maintain good health. However,
the immune system deteriorates with advancing age, and this contributes to increased …

Innate and adaptive immune functions decline with age, leading to increased susceptibility
to infectious diseases and cancer, and reduced responses to preventive vaccination in the …

Highlights•Neutrophils are increasingly recognized as multi-faceted immune cells.•In aged
hosts, neutrophils show inaccurate chemotaxis and reduced NET formation.•Neutrophils …

Ageing is a global burden. Increasing age is associated with increased incidence of
infections and cancer and decreased vaccine efficacy. This increased morbidity observed …

Despite increasing longevity, many old people are not in good health. There has been an
increase in the prevalence of age-associated multi-morbidity (two or more chronic conditions …

It is well known that the immune response decreases during aging, leading to a higher
susceptibility to infections, cancers and autoimmune disorders. Most widely studied have …

Senescence is a cellular program that prevents the replication of old, damaged, or
cancerous cells. Senescent cells become growth arrested and undergo changes in their …