BDNF mRNA is decreased in the hippocampus of individuals with Alzheimer's disease

HS Phillips, JM Hains, M Armanini, GR Laramee… - Neuron, 1991 - cell.com
In recent years, nerve growth factor (NGF) has gained attention as a potential therapeutic
agent for Alzheimer's disease (AD). To study the expression of NGF and its homologs, brain …

Brain-derived neurotrophic factor and neurotrophin-3 levels in Alzheimer's disease brains

N Durany, T Michel, J Kurt, FF Cruz-Sánchez… - International Journal of …, 2000 - Elsevier
In the present study, we investigated the levels of brain-derived neurotrophic factor (BDNF)
and neurotrophin-3 (NT-3) in post-mortem brain tissue of Alzheimer's disease (AD) patients …

Brain-derived neurotrophic factor is reduced in Alzheimer's disease

B Connor, D Young, Q Yan, RLM Faull, B Synek… - Molecular brain …, 1997 - Elsevier
Alzheimer's disease may be due to a deficiency in neurotrophin protein or receptor
expression. Consistent with this hypothesis, a reduction in BDNF mRNA expression has …

Pro-brain-derived neurotrophic factor is decreased in parietal cortex in Alzheimer's disease

B Michalski, M Fahnestock - Molecular Brain Research, 2003 - Elsevier
Brain-derived neurotrophic factor (BDNF) promotes the function and survival of the major
neuronal types affected in Alzheimer disease, such as hippocampal, cortical and basal …

Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease

S Peng, DJ Garzon, M Marchese, W Klein… - Journal of …, 2009 - Soc Neuroscience
Downregulation of brain-derived neurotrophic factor (BDNF) in the cortex occurs early in the
progression of Alzheimer's disease (AD). Since BDNF plays a critical role in neuronal …

Precursor form of brain‐derived neurotrophic factor and mature brain‐derived neurotrophic factor are decreased in the pre‐clinical stages of Alzheimer's disease

S Peng, J Wuu, EJ Mufson… - Journal of …, 2005 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) is critical for the function and survival of neurons
that degenerate in the late stage of Alzheimer's disease (AD). There are two forms of BDNF …

[图书][B] Neurotrophic factors and Alzheimer's disease: are we focusing on the wrong molecule?

M Fahnestock, D Garzon, RMD Holsinger, B Michalski - 2002 - Springer
Brain derived neurotrophic factor (BDNF) promotes cholinergic neuron function and survival.
In Alzheimer's disease, BDNF mRNA and protein are decreased in basal forebrain …

Induction of brain-derived neurotrophic factor in plaque-associated glial cells of aged APP23 transgenic mice

GJ Burbach, R Hellweg, CA Haas… - Journal of …, 2004 - Soc Neuroscience
Brain-derived neurotrophic factor (BDNF) is a versatile neurotrophic factor that has been
implicated in cell survival, cell differentiation, axonal growth, and activity-dependent synaptic …

Brain-derived neurotrophic factor in Alzheimer's disease: risk, mechanisms, and therapy

JH Song, JT Yu, L Tan - Molecular neurobiology, 2015 - Springer
Brain-derived neurotrophic factor (BDNF) has a neurotrophic support on neuron of central
nervous system (CNS) and is a key molecule in the maintenance of synaptic plasticity and …

A new brain‐derived neurotrophic factor transcript and decrease inbrain‐derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex

D Garzon, G Yu, M Fahnestock - Journal of neurochemistry, 2002 - Wiley Online Library
Brain‐derived neurotrophic factor (BDNF) supports hippocampal, cortical and basal
forebrain cholinergic neurons, which lose function in Alzheimer's disease. In Alzheimer's …