Identification of a novel binding mechanism of Quinoline based molecules with lactate dehydrogenase of Plasmodium falciparum
R Singh, V Bhardwaj, R Purohit - Journal of Biomolecular Structure …, 2021 - Taylor & Francis
The deadliest disease caused by the Plasmodium species is malaria. Among other species,
the infection caused by Plasmodium falciparum (Pf) is life-threatening. The biological …
the infection caused by Plasmodium falciparum (Pf) is life-threatening. The biological …
Antimalarial Activity of Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme Selected by Docking Studies
J Penna-Coutinho, WA Cortopassi, AA Oliveira… - PloS one, 2011 - journals.plos.org
The Plasmodium falciparum lactate dehydrogenase enzyme (Pf LDH) has been considered
as a potential molecular target for antimalarials due to this parasite's dependence on …
as a potential molecular target for antimalarials due to this parasite's dependence on …
Molecular docking, simulation and binding free energy analysis of small molecules as PfHT1 inhibitors
Antimalarial drug resistance has thrown a spanner in the works of malaria elimination. New
drugs are required for ancillary support of existing malaria control efforts. Plasmodium …
drugs are required for ancillary support of existing malaria control efforts. Plasmodium …
Synthesis, in vitro and in silico antimalarial activity of 7-chloroquinoline and 4H-chromene conjugates
A Parthiban, J Muthukumaran, A Manhas… - Bioorganic & medicinal …, 2015 - Elsevier
A new series of chloroquinoline-4H-chromene conjugates incorporating piperizine or
azipane tethers were synthesized and their anti-malarial activity were evaluated against two …
azipane tethers were synthesized and their anti-malarial activity were evaluated against two …
[HTML][HTML] Molecular docking analysis of phyto-constituents from Cannabis sativa with pfDHFR
Available antimalarial drugs have been associated with numerous side effects, which
include skin rashes and myelo-suppression. Therefore, it is of interest to explore compounds …
include skin rashes and myelo-suppression. Therefore, it is of interest to explore compounds …
[HTML][HTML] Identification of novel Plasmodium falciparum dihydroorotate dehydrogenase inhibitors for malaria using in silico studies
AA Alzain, ZAM Ahmed, MA Mahadi, FA Elbadwi - Scientific African, 2022 - Elsevier
Malaria, that ancient infectious disease is considered a great health problem due to its
highly infectious and mortality rates. The more harmful kind of malaria is Plasmodium …
highly infectious and mortality rates. The more harmful kind of malaria is Plasmodium …
Antimalarial properties and molecular docking analysis of compounds from Dioscorea bulbifera L. as new antimalarial agent candidates
Background At present, the emergence and spread of antimalarial drug resistance has
become a significant problem worldwide. There has been a challenge in searching for …
become a significant problem worldwide. There has been a challenge in searching for …
Febrifugine analogues as Leishmania donovani trypanothione reductase inhibitors: binding energy analysis assisted by molecular docking, ADMET and molecular …
Visceral leishmaniasis affects people from 70 countries worldwide, mostly from Indian,
African and south American continent. The increasing resistance to antimonial, miltefosine …
African and south American continent. The increasing resistance to antimonial, miltefosine …
1, 2, 3-Triazole derivatives: Synthesis, docking, cytotoxicity analysis and in vivo antimalarial activity
FV Lopes, PHF Stroppa, JA Marinho, RR Soares… - Chemico-Biological …, 2021 - Elsevier
Malaria remains one of the most important parasitic diseases in the world. The multidrug-
resistant Plasmodium strains make the treatment currently available for malaria less …
resistant Plasmodium strains make the treatment currently available for malaria less …
[HTML][HTML] In silico screening of phytochemicals from Dissotis rotundifolia against Plasmodium falciparum Dihydrofolate Reductase
Background Malaria remains a major health concern in developing countries with high
morbidity and mortality, especially in pregnant women and infants. A major obstacle to the …
morbidity and mortality, especially in pregnant women and infants. A major obstacle to the …