Cancer is a leading cause of death across the world and continues to increase in incidence.
Despite years of research, multiple tumors (eg, glioblastoma, pancreatic cancer) still have …

In vitro cancer models are envisioned as high-throughput screening platforms for potential
new therapeutic discovery and/or validation. They also serve as tools to achieve …

Digestive system cancers account for nearly half of all cancers around the world and have a
high mortality rate. Cell culture and animal models represent cornerstones of digestive …

Highlights•Drug discovery is expensive and time consuming.•Failure of anticancer drugs is a
major clinical challenge.•Two-dimensional cancer cell cultures do not completely reproduce …

In vitro tumor models have provided important tools for cancer research and serve as low-
cost screening platforms for drug therapies; however, cancer recurrence remains largely …

Cancer therapies have several clinical challenges associated with them, namely treatment
toxicity, treatment resistance and relapse. Due to factors ranging from patient profiles to the …

Personalized cancer therapy focuses on characterizing the relevant phenotypes of the
patient, as well as the patient's tumor, to predict the most effective cancer therapy …

Simple Summary Cancer is a leading cause of death worldwide. While numerous studies
have been conducted on cancer treatment, clinical treatment options for cancers are still …

In recent years, many research groups have begun to utilize bioengineered in vitro models
of cancer to study mechanisms of disease progression, test drug candidates, and develop …

Simple Summary Novel strategies that aim at personalizing cancer therapy are in rapid
evolution. In the past decade, new methods to test for the efficacy of either standard-of-care …