Tanshinone IIA inhibits HIF-1α and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway
Hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) play
important roles in angiogenesis and tumor growth. Tanshinone IIA (T2A) is a novel …
important roles in angiogenesis and tumor growth. Tanshinone IIA (T2A) is a novel …
[HTML][HTML] Tanshinone I inhibits tumor angiogenesis by reducing Stat3 phosphorylation at Tyr705 and hypoxia-induced HIF-1α accumulation in both endothelial and …
Y Wang, JX Li, YQ Wang, ZH Miao - Oncotarget, 2015 - ncbi.nlm.nih.gov
Abstract Tanshinone I (Tanshinone-1), a major active principle of Salvia miltiorrhiza
(Danshen), has been shown to overcome tumor drug resistance and metastasis. Here we …
(Danshen), has been shown to overcome tumor drug resistance and metastasis. Here we …
Regulation of the cell cycle and PI3K/Akt/mTOR signaling pathway by tanshinone I in human breast cancer cell lines Retraction in/10.3892/mmr. 2021.12080
L Wang, J Wu, J Lu, R Ma… - Molecular medicine …, 2015 - spandidos-publications.com
Breast cancer is the second leading cause of cancer‑related mortality in females worldwide.
Therefore, identifying alternative strategies to combat the disease mortality is important. The …
Therefore, identifying alternative strategies to combat the disease mortality is important. The …
Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling Pathway
Z Wang, N Wang, S Han, D Wang, S Mo, L Yu… - PloS one, 2013 - journals.plos.org
Angiogenesis is crucial for cancer initiation, development and metastasis. Identifying natural
botanicals targeting angiogenesis has been paid much attention for drug discovery in recent …
botanicals targeting angiogenesis has been paid much attention for drug discovery in recent …
[HTML][HTML] Anti-angiogenic effect of tanshinone IIA involves inhibition of the VEGF/VEGFR2 pathway in vascular endothelial cells
Y Xing, J Tu, L Zheng, L Guo, T Xi - Oncology reports, 2015 - spandidos-publications.com
Tanshinone IIA (TSA) is one of the major lipophilic components of Salvia miltiorrhiza Bunge
reported to exhibit an antitumor effect. The exact intracellular signaling mechanisms …
reported to exhibit an antitumor effect. The exact intracellular signaling mechanisms …
Tanshinone IIA inhibits breast cancer stem cells growth in vitro and in vivo through attenuation of IL‐6/STAT3/NF‐kB signaling pathways
C Lin, L Wang, H Wang, L Yang… - Journal of cellular …, 2013 - Wiley Online Library
Cancer stem cells (CSCs) are maintained by inflammatory cytokines and signaling
pathways. Tanshinone IIA (Tan‐IIA) possesses anti‐cancer and anti‐inflammatory activities …
pathways. Tanshinone IIA (Tan‐IIA) possesses anti‐cancer and anti‐inflammatory activities …
Tanshinone IIA attenuates insulin like growth factor 1-induced cell proliferation in PC12 cells through the PI3K/Akt and MEK/ERK pathways
The insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) facilitate tumor proliferation
and progression. Tanshinone IIA (TSN) is an active diterpene quinone isolated from the …
and progression. Tanshinone IIA (TSN) is an active diterpene quinone isolated from the …
[HTML][HTML] The antitumor effect of tanshinone IIA on anti-proliferation and decreasing VEGF/VEGFR2 expression on the human non-small cell lung cancer A549 cell line
J Xie, J Liu, H Liu, S Liang, M Lin, Y Gu, T Liu… - … Pharmaceutica Sinica B, 2015 - Elsevier
The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell
line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were …
line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were …
[HTML][HTML] Tanshinone IIA suppresses ovarian cancer growth through inhibiting malignant properties and angiogenesis
J Zhou, YY Jiang, XX Wang, HP Wang… - Annals of …, 2020 - ncbi.nlm.nih.gov
Background In Chinese herbal medicine, Tanshinone IIA (Tan-IIA) is one of the main
compounds extracted from Salvia miltiorrhiza Bunge. Tan-IIA has been demonstrated to …
compounds extracted from Salvia miltiorrhiza Bunge. Tan-IIA has been demonstrated to …
Tanshinone IIA can inhibit MiaPaCa-2 human pancreatic cancer cells by dual blockade of the Ras/Raf/MEK/ERK and PI3K/AKT/mTOR pathways
CC Su - Oncology reports, 2018 - spandidos-publications.com
Tanshinone IIA (Tan-IIA; C19H18O3) is derived from Danshen (the roots of Salvia
miltiorrhiza), and has been reported to possess anti-inflammatory and antioxidant activities …
miltiorrhiza), and has been reported to possess anti-inflammatory and antioxidant activities …
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