Hypoxia-inducible factor 1α (HIF-1α) and vascular endothelial growth factor (VEGF) play
important roles in angiogenesis and tumor growth. Tanshinone IIA (T2A) is a novel …

Abstract Tanshinone I (Tanshinone-1), a major active principle of Salvia miltiorrhiza
(Danshen), has been shown to overcome tumor drug resistance and metastasis. Here we …

Breast cancer is the second leading cause of cancer‑related mortality in females worldwide.
Therefore, identifying alternative strategies to combat the disease mortality is important. The …

Angiogenesis is crucial for cancer initiation, development and metastasis. Identifying natural
botanicals targeting angiogenesis has been paid much attention for drug discovery in recent …

Tanshinone IIA (TSA) is one of the major lipophilic components of Salvia miltiorrhiza Bunge
reported to exhibit an antitumor effect. The exact intracellular signaling mechanisms …

Cancer stem cells (CSCs) are maintained by inflammatory cytokines and signaling
pathways. Tanshinone IIA (Tan‐IIA) possesses anti‐cancer and anti‐inflammatory activities …

The insulin like growth factor 1 (IGF-1) and its receptor (IGF-1R) facilitate tumor proliferation
and progression. Tanshinone IIA (TSN) is an active diterpene quinone isolated from the …

The effects of tanshinone IIA on the proliferation of the human non-small cell lung cancer cell
line A549 and its possible mechanism on the VEGF/VEGFR signal pathway were …

Background In Chinese herbal medicine, Tanshinone IIA (Tan-IIA) is one of the main
compounds extracted from Salvia miltiorrhiza Bunge. Tan-IIA has been demonstrated to …

Tanshinone IIA (Tan-IIA; C19H18O3) is derived from Danshen (the roots of Salvia
miltiorrhiza), and has been reported to possess anti-inflammatory and antioxidant activities …