Inflammation is known to play a critical role in all stages of tumorigenesis; however, less is
known about how it predisposes the tissue microenvironment preceding tumor formation …

Chronic wounds present a major disease burden in people with recessive dystrophic
epidermolysis bullosa (RDEB), an inherited blistering skin disorder caused by mutations in …

Recessive dystrophic epidermolysis bullosa (RDEB) is a skin fragility disease caused by
mutations that affect the function and/or the amount of type VII collagen (C7), the major …

The extracellular matrix protein collagen VII is part of the microenvironment of stratified
epithelia and critical in organismal homeostasis. Mutations in the encoding gene COL7A1 …

Recessive dystrophic epidermolysis bullosa (RDEB) is a genetic extracellular matrix disease
caused by deficiency in type VII collagen (Col VII). The disease manifests with devastating …

Background: Individuals with severe generalized recessive dystrophic epidermolysis bullosa
(RDEB), an inherited blistering disorder caused by mutations in the COL7A1 gene, develop …

Recessive dystrophic epidermolysis bullosa (RDEB), a genetic skin blistering disease, is a
paradigmatic condition of tissue fragility‐driven multi‐organ fibrosis. Here, longitudinal …

Although a host of intracellular signals is known to contribute to wound healing, the role of
the cell microenvironment in tissue repair remains elusive. Here we employed 2 different …

Patients with the genetic skin blistering disease recessive dystrophic epidermolysis bullosa
(RDEB) develop aggressive cutaneous squamous cell carcinoma (cSCC). Metastasis …

Background Cutaneous squamous cell carcinomas (cSCC) are the primary cause of
premature deaths in patients suffering from the rare skin-fragility disorder recessive …