Reactive oxygen species impact on sperm DNA and its role in male infertility

AD Bui, R Sharma, R Henkel, A Agarwal - Andrologia, 2018 - Wiley Online Library
Reactive oxygen species (ROS) have been extensively studied as a cause of male infertility.
Excessive levels of ROS coupled with a deficiency in antioxidants can lead to oxidative …

Oxidative stress and male infertility—a clinical perspective

K Tremellen - Human reproduction update, 2008 - academic.oup.com
Oxidative stress occurs when the production of potentially destructive reactive oxygen
species (ROS) exceeds the bodies own natural antioxidant defenses, resulting in cellular …

Oxidative stress and its implications in female infertility–a clinician's perspective

A Agarwal, S Gupta, R Sharma - Reproductive biomedicine online, 2005 - Elsevier
Reactive oxygen species (ROS) have a role in the modulation of gamete quality and gamete
interaction. Generation of ROS is inherent in spermatozoa and contaminating leukocytes …

Damage to sperm DNA mediated by reactive oxygen species: its impact on human reproduction and the health trajectory of offspring

D Gavriliouk, RJ Aitken - The male role in pregnancy loss and embryo …, 2015 - Springer
Disruptions to the genetic integrity of the mammalian spermatozoon play a major role in
determining the subsequent developmental trajectory of the embryo. This chapter examines …

Oxidative stress and male infertility

S Bisht, M Faiq, M Tolahunase, R Dada - Nature Reviews Urology, 2017 - nature.com
DNA damage, largely owing to oxidative stress, is a leading cause of defective sperm
function. High levels of oxidative stress result in damage to sperm DNA, RNA transcripts …

[PDF][PDF] Oxidative stress, DNA damage and apoptosis in male infertility: a clinical approach

A Agarwal, TM Said - BJU international, 2005 - academia.edu
All living aerobic cells are normally exposed to some reactive oxygen species (ROS) but if
ROS levels rise, oxidative stress (OS) occurs, which results in oxygen and oxygen-derived …

Markers of oxidative stress and sperm chromatin integrity

A Agarwal, AC Varghese, RK Sharma - Molecular endocrinology: Methods …, 2009 - Springer
Oxidative stress (OS) is an imbalance between the amount of reactive oxygen species
(ROS) produced and the ability of the antioxidants to scavenge these. OS has been …

Clinical relevance of oxidative stress in male factor infertility: an update

A Agarwal, K Makker, R Sharma - American journal of …, 2008 - Wiley Online Library
Male factor has been considered a major contributory factor to infertility. Along with the
conventional causes for male infertility such as varicocele, cryptorchidism, infections …

[HTML][HTML] Role of oxidative stress in male infertility: an updated review

AT Alahmar - Journal of human reproductive sciences, 2019 - journals.lww.com
Current evidence links oxidative stress (OS) to male infertility, reduced sperm motility, sperm
DNA damage and increased risk of recurrent abortions and genetic diseases. A review of …

Reactive oxygen species in seminal plasma as a cause of male infertility

N Kumar, AK Singh - Journal of gynecology obstetrics and human …, 2018 - Elsevier
Male factor is responsible for 40–50% of infertility cases, contributing equally as a female
factor. Oxidative stress has now emerged as one of the major causes of unexplained male …